drugset / Trial / NCT00199511
Hypertonic Saline 75% vs Mannitol 20%
Completed
162 enrolled
London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
RandomizedParallel-groupDouble-blindTreatment
Summary
The purpose of this study is to evaluate the effect of Hypertonic Saline 7.5% vs Mannitol 20% on brain bulk (using a 4 point scale), intracranial pressure (subdural catheter)and the changes on serum and urinary Na, K and Osmolarity during elective craniotomy for brain tumor resection.
Timeline
- Start
- 2005-01
- Primary completion
- —
- Completion
- 2007-04
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Hypertonic saline | Unknown | 7.5 % | — |
| Subject | Mannitol | Diagnostic / imaging agent | 20 % | — |