Drugs / Hypertonic saline
Hypertonic saline
also known as
HTS · 3% Sodium Chloride · ClNa 3% (sodium chloride 3%) · Hyper-Sal, inhaled saline · hyperosmolar saline · Hypertonic Saline Solution · Plabottle
Trials 62 · started per year
today
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Also used as a comparator or background therapy in 29 trials
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 02 trials | ||||||
| Phase 0 | NCT06174584 Comparator | Feb 2021 → Jan 2022 | rectal prolapse | Shaheed Zulfiqar Ali Bhutto Medical University | Completed | No outcome recorded |
| Phase 0 | NCT04686344 Comparator | Dec 2020 → Aug 2021 | optic nerve disorder | Cairo University | Completed | No outcome recorded |
| Phase 11 trial | ||||||
| Phase 1 | NCT01223183 Comparator | Sep 2010 → Dec 2012 | cystic fibrosis | University of Pittsburgh | Completed | No outcome recorded |
| Phase 1/21 trial | ||||||
| Phase 1/2 | NCT00928135 Comparator | Jan 2013 → Apr 2018 | cystic fibrosis | Joseph Zabner | Completed | No outcome recorded |
| Phase 27 trials | ||||||
| Phase 2 | NCT04671407 Comparator | Jan 2021 → Dec 2022 | — | Kaplan Medical Center | Unknown | No outcome recorded |
| Phase 2 | NCT02709109 Background | Feb 2016 → Sep 2017 | cystic fibrosis | Parion Sciences | Completed | No outcome recorded |
| Phase 2 | NCT02585531 Comparator | Nov 2015 → Feb 2017 | bronchiolitis | Hospital General Naval de Alta Especialidad - Escuela Medico Naval | Unknown | No outcome recorded |
| Phase 2 | NCT01954290 Comparator | Sep 2015 | brain edema, stroke disorder | University of Florida | Withdrawn | No outcome recorded |
| Phase 2 | NCT02343445 Background | Apr 2015 → Feb 2016 | cystic fibrosis | Parion Sciences | Completed | No outcome recorded |
| Phase 2 | NCT00677729 Comparator | Nov 2008 → Apr 2009 | bronchiolitis | Queen's University | Completed | No outcome recorded |
| Phase 2 | NCT00696540 Background | Jun → Sep 2008 | bronchiolitis | University Diego Portales | Unknown | No outcome recorded |
| Phase 33 trials | ||||||
| Phase 3 | NCT06110429 Comparator | Jan 2024 → Jun 2025 | intracranial hypertension | University Hospital, Geneva | Unknown | No outcome recorded |
| Phase 3 | NCT01111682 Comparator | Apr → Nov 2010 | intracranial hypertension, traumatic brain injury | University of Cincinnati | Terminated | No outcome recorded |
| Phase 3 | NCT00484263 Comparator | Dec 2007 → Oct 2009 | bronchiectasis | The Alfred | Completed | No outcome recorded |
| Phase 45 trials | ||||||
| Phase 4 | NCT04765033 Comparator | Feb 2021 → Aug 2023 | bronchiectasis | University of Malaya | Completed | No outcome recorded |
| Phase 4 | NCT03280745 Comparator | Feb 2018 → May 2019 | cardiac valvular defect, cardiovascular disorder | Insel Gruppe AG, University Hospital Bern | Completed | No outcome recorded |
| Phase 4 | NCT02538458 Comparator | Nov 2014 → Mar 2016 | acute bronchiolitis | University Hospital, Grenoble | Completed | No outcome recorded |
| Phase 4 | NCT01276821 Comparator | Jan → Apr 2011 | bronchiolitis | Dr. Aayush Khanal, MD | Completed | No outcome recorded |
| Phase 4 | NCT01377792 Comparator | Mar 2009 → May 2011 | cystic fibrosis | Adelaida Lamas Ferreiro | Completed | No outcome recorded |
| Phase not applicable10 trials | ||||||
| — | NCT07286409 Comparator | Jan → Dec 2026 expected | acute respiratory distress syndrome | Tanta University | Not yet recruiting | No outcome recorded |
| — | NCT06069336 Comparator | Nov 2023 → Apr 2025 | acute bronchiolitis | Szpital im. Św. Jadwigi Śląskiej | Completed | No outcome recorded |
| — | NCT04314674 Comparator | Apr 2020 → Apr 2022 | adult glioblastoma, metastatic malignant neoplasm in the brain | Istanbul University | Unknown | No outcome recorded |
| — | NCT04146311 Comparator | Oct 2019 → Nov 2020 | osteoarthritis, knee | Aalborg University | Completed | No outcome recorded |
| — | NCT03741257 Comparator | Nov 2018 → Nov 2019 | — | Cairo University | Unknown | No outcome recorded |
| — | NCT03614273 Comparator | Mar 2015 → Feb 2016 | bronchiolitis | Maulana Azad Medical College | Completed | No outcome recorded |
| — | NCT02460510 Comparator | Jun 2014 → Nov 2015 | acute liver failure | Institute of Liver and Biliary Sciences, India | Completed | No outcome recorded |
| — | NCT01108744 Comparator | Jan 2012 → Jan 2014 | intracranial hypertension | Beth Israel Deaconess Medical Center | Withdrawn | No outcome recorded |
| — | NCT01073527 Comparator | Jan 2009 → Jul 2011 | asthma | Wolfson Medical Center | Completed | No outcome recorded |
| — | NCT00671723 Comparator | Oct 2006 → Jul 2008 | lung disorder | University of Oklahoma | Completed | No outcome recorded |
Evidence & citations 10 cited values
Every value below carries the sentence it was read from. 92 sources stand behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | Hypertonic Saline | “Hypertonic saline: Nebulized hypertonic saline has been suggested as a potential therapy for ARDS patients due to its ability to reduce airway inflammation and improve...” NCT07286409 ↗88“Nebulized hypertonic saline (HS) has been shown to increase mucociliary clearance in the airways of individuals with healthy lungs.” NCT01247064 ↗ “After the head fixation 3 mL.kg-1 %3 hypertonic saline will be administered over the 20 min intravenously.” NCT04314674 ↗ “The two hypertonic solutions most commonly used are Mannitol 20% and Hypertonic Saline 7.5%.” NCT00199511 ↗ “Periurethral hypertonic saline (10% NaCl) injection” NCT04812574 ↗ “2% hypertonic saline (Plabottle® by Otsuka Inc.)” PMID 32928313 ↗ Sep 2020 “nebulized hypertonic saline (HS) treatment” PMID 28586918 ↗ Aug 2017 “Hypertonic saline (HTS) is a compound” NCT02432157 ↗ “hypertonic saline (10 mL)” NCT07411950 ↗ “Drug: Hypertonic saline” NCT01355796 ↗ |
| Known as | 3% Sodium Chloride | ClinicalTrials.gov intervention name — accepted as the source's own label NCT02233985 ↗ |
| Known as | ClNa 3% (sodium chloride 3%) | “ClNa 3% (sodium chloride 3%)” NCT01238848 ↗ |
| Known as | HTS | “There has been substantial retrospective data and limited prospective data in children which suggests that hypertonic saline (HTS) can improve the control of intracranial...” NCT00142090 ↗2“Inhalation of hypertonic saline (HTS) has short term positive effects on airways clearance in non-cystic fibrosis (CF) bronchiectasis, however its long term effects are unknown.” PMID 22349069 ↗ Feb 2012 “Hypertonic saline (HTS) is a compound” NCT02432157 ↗ |
| Known as | Hyper-Sal, inhaled saline | “Hyper-Sal™, inhaled saline” NCT02378467 ↗ |
| Known as | hyperosmolar saline | “Hyperosmolar saline is an irrigation solution with a higher concentration of solutes that will be used intraoperatively to washout the surgical field.” NCT03738735 ↗ |
| Known as | Hypertonic Saline Solution | “Sodium Lactate Versus Hypertonic Saline Solution in the Treatment of Intracranial Hypertensive Episodes in Severe Brain Injured Patients” NCT06110429 ↗ |
| Known as | Plabottle | “2% hypertonic saline (Plabottle® by Otsuka Inc.)” PMID 32928313 ↗ Sep 2020 |
| Action | Inhibit | “exerts inhibitory effects in several stages of the inflammatory cascade” NCT06226402 ↗ |
| Route | Intravenous | “3% hypertonic saline (salt-water solution) given in a vein” NCT00142090 ↗ |