Nebulized Hypertonic Saline for Inpatient Use in COPD

Summary

A comparison of albuterol treatments using hypertonic saline (3%) versus standard saline (0.9%) in patients with admitted patients COPD in regard to Modified Borg Dyspnea scale scores after 4 treatments within 24 hours.

Timeline

Start

2014-10

Primary completion

2017-01-30

Completion

2017-01-30

Outcome

Missed primary endpoint

registry MEAN Hypertonic Saline: -1.4 (Standard Deviation 1.6) units on a scale NCT02266875 ↗

registry analysis (superiority test); Hypertonic Saline vs Standard Saline; p = 0.320; t-test, 2 sided NCT02266875 ↗

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Hypertonic saline	Unknown	3 %	Other

Indications