drugset / Trial / NCT00696540
Hypertonic Saline for Outpatient Bronchiolitis
RandomizedParallel-groupQuadruple-blindTreatment
Summary
We will study if small children who become ill with respiratory distress during the RSV epidemic are better relieved with salbutamol nebulizations diluted in hypertonic (3%), instead of normal (0.9%) saline.
Timeline
- Start
- 2008-06
- Primary completion
- 2008-09
- Completion
- 2008-10
Publications
- Background Sarrell EM, Tal G, Witzling M, Someck E, Houri S, Cohen HA, Mandelberg A. Nebulized 3% hypertonic saline solution treatment in ambulatory children with viral bronchiolitis decreases symptoms. Chest. 2002 Dec;122(6):2015-20. doi: 10.1378/chest.122.6.2015.
- Background Mandelberg A, Tal G, Witzling M, Someck E, Houri S, Balin A, Priel IE. Nebulized 3% hypertonic saline solution treatment in hospitalized infants with viral bronchiolitis. Chest. 2003 Feb;123(2):481-7. doi: 10.1378/chest.123.2.481.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Salbutamol | Unknown | 0.5 mg | Inhaled |
| Background | Hypertonic saline | Unknown | 3 % | Inhaled |
| Background | Hypertonic saline | Unknown | 3.5 ml | Inhaled |
| Comparator | sodium chloride | Unknown | 0.9 % | Inhaled |
| Comparator | sodium chloride | Unknown | 3.5 ml | Inhaled |