A Randomised Efficacy Study of Combination Antimalarials to Treat Uncomplicated Malaria

NCT00203814 ↗

Completed 280 enrolled University of Cape Town Medical Research Council, South Africa · collab World Health Organization · collab

RandomizedParallel-groupOpen-labelTreatment

Summary

The purpose of this study is to determine the efficacy of sulfadoxine-pyrimethamine plus artesunate versus sulfadoxine-pyrimethamine alone in the treatment of uncomplicated malaria.

Timeline

Start: 2004-01
Primary completion: —
Completion: 2005-03

Outcome

Met primary endpoint

paper treatment with AS/SP decreased the relative hazard of treatment failure by 80% compared to SP (hazard ratio [HR] 0.2; 95% CI 0.1-0.6) PMID 19558654 ↗

Publications

Allen EN, Little F, Camba T, Cassam Y, Raman J, Boulle A, Barnes KI. Efficacy of sulphadoxine-pyrimethamine with or without artesunate for the treatment of uncomplicated Plasmodium falciparum malaria in southern Mozambique: a randomized controlled trial. Malar J. 2009 Jun 26;8:141. doi: 10.1186/1475-2875-8-141.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Artesunate	Small molecule	4 mg/kg	—
Subject	Sulfadoxine-pyrimethamine	Small molecule	1.25 mg/kg	—
Subject	Sulfadoxine-pyrimethamine	Small molecule	25 mg/kg	—