Sulfadoxine-pyrimethamine
Trials 36
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 1/21 trial | ||||||
| Phase 1/2 | NCT01328990 | Apr → Jul 2011 | malaria | London School of Hygiene and Tropical Medicine | Completed | No outcome recorded |
| Phase 21 trial | ||||||
| Phase 2 | NCT00486694 | Mar → Aug 2004 | Plasmodium vivax malaria | London School of Hygiene and Tropical Medicine | Completed | No outcome recorded |
| Phase 2/32 trials | ||||||
| Phase 2/3 | NCT00084240 | Mar 2004 → Apr 2005 | Plasmodium falciparum malaria | Pfizer | Terminated | No outcome recorded |
| Phase 2/3 | NCT00074841 | Sep 2003 → Jan 2005 | Plasmodium falciparum malaria | Pfizer | Completed | No outcome recorded |
| Phase 39 trials · 2 met primary · 2 missed | ||||||
| Phase 3 | NCT05471544 | Jul 2022 → Dec 2024 | malaria | Malaria Consortium | Unknown | No outcome recorded |
| Phase 3 | NCT01722539 | Nov 2012 → Nov 2013 | — | University of Antwerp | Completed | No outcome recorded |
| Phase 3 | NCT01449045 | Jul → Dec 2011 | malaria | Cheikh Anta Diop University, Senegal | Completed | Met primary |
| Phase 3 | NCT00152204 | Mar 2005 → Dec 2007 | Plasmodium falciparum malaria, anemia | Swiss Tropical & Public Health Institute | Unknown | Missed primary |
| Phase 3 | NCT00142246 | Jan 2005 → Apr 2006 | Plasmodium falciparum malaria | London School of Hygiene and Tropical Medicine | Completed | Met primary |
| Phase 3 | NCT00730366 | Mar 2004 → Oct 2006 | Plasmodium falciparum malaria | Institute of Tropical Medicine, Belgium | Completed | No outcome recorded |
| Phase 3 | NCT00118807 | Aug 2003 → Feb 2004 | Plasmodium falciparum malaria | London School of Hygiene and Tropical Medicine | Completed | No outcome recorded |
| Phase 3 | NCT00131716 | May 2003 → May 2005 | anemia | London School of Hygiene and Tropical Medicine | Completed | Missed primary |
| Phase 3 | NCT00289250 | May → Dec 2001 | Plasmodium falciparum malaria | London School of Hygiene and Tropical Medicine | Completed | No outcome recorded |
| Phase 413 trials · 2 missed | ||||||
| Phase 4 | NCT07322068 | Sep 2026 → Jun 2033 expected | Plasmodium falciparum malaria | Stanford University | Not yet recruiting | No outcome recorded |
| Phase 4 | NCT06083688 | Oct 2024 → Jul 2025 overdue | Plasmodium falciparum malaria, anemia | Liverpool School of Tropical Medicine | Active not recruiting | No outcome recorded |
| Phase 4 | NCT05980156 | Feb → Jul 2023 | Plasmodium falciparum malaria, anemia | University of Maryland, Baltimore | Completed | No outcome recorded |
| Phase 4 | NCT05478954 | Jul → Oct 2022 | malaria | Malaria Consortium | Unknown | No outcome recorded |
| Phase 4 | NCT01184911 | Oct 2010 → Sep 2011 | malaria | University of California, San Francisco | Withdrawn | No outcome recorded |
| Phase 4 | NCT00712374 | Sep 2008 → Dec 2011 | malaria | London School of Hygiene and Tropical Medicine | Unknown | Missed primary |
| Phase 4 | NCT00453856 | Mar 2007 → ? | malaria | Albert Schweitzer Hospital, Netherlands | Terminated | No outcome recorded |
| Phase 4 | NCT00130065 | Nov 2003 → Feb 2006 | malaria | Centers for Disease Control and Prevention | Completed | No outcome recorded |
| Phase 4 | NCT00167739 | Apr 2003 → Feb 2004 | malaria | Albert Schweitzer Hospital | Completed | No outcome recorded |
| Phase 4 | NCT00167843 | Dec 2002 → Mar 2007 | malaria | Albert Schweitzer Hospital | Completed | No outcome recorded |
| Phase 4 | NCT00270530 | Nov 2002 → Oct 2004 | HIV infectious disease, malaria, pregnancy disorder with abortive outcome | Center for International Health and Development | Completed | Missed primary |
| Phase 4 | NCT00144352 | Sep 2002 → Jul 2004 | AIDS, Plasmodium falciparum malaria | Centers for Disease Control and Prevention | Completed | No outcome recorded |
| Phase 4 | NCT00137553 | May 2001 → Mar 2004 | Plasmodium falciparum malaria | Bandim Health Project | Completed | No outcome recorded |
| Phase not applicable10 trials · 2 met primary · 2 missed | ||||||
| — | NCT02351687 | Apr 2014 → Jun 2016 | protein-energy malnutrition | Washington University School of Medicine | Completed | Missed primary |
| — | NCT00766662 | Oct 2006 → Dec 2007 | malaria | University of Bamako | Completed | No outcome recorded |
| — | NCT00127998 | Jul 2005 → ? | malaria | Centers for Disease Control and Prevention | Completed | No outcome recorded |
| — | NCT00111163 | Mar 2004 → Mar 2006 | anemia, malaria | Centers for Disease Control and Prevention | Completed | Mixed |
| — | NCT00203814 | Jan 2004 → Mar 2005 | Plasmodium falciparum malaria | University of Cape Town | Completed | Met primary |
| — | NCT00287300 | Sep 2003 → Aug 2005 | malaria | University of North Carolina | Completed | No outcome recorded |
| — | NCT00209781 | Aug 2003 → Dec 2006 | pregnancy disorder | Hospital Clinic of Barcelona | Unknown | Missed primary |
| — | NCT00229775 | Jul 2003 → Jul 2008 | malaria | Centers for Disease Control and Prevention | Completed | No outcome recorded |
| — | NCT00623155 | Jul 2002 → Jul 2003 | malaria | University of Bamako | Completed | Met primary |
| — | NCT00203801 | Jan 2002 → Jul 2005 | malaria | University of Cape Town | Completed | No outcome recorded |
| Comparator or background therapy22 trials | ||||||
| Phase 2 | NCT00323622 Background | Apr 2005 → May 2007 | malaria | GlaxoSmithKline | Completed | No outcome recorded |
| Phase 3 | NCT06166498 Comparator | Jul → Dec 2024 | malaria | London School of Hygiene and Tropical Medicine | Completed | No outcome recorded |
| Phase 3 | NCT05426434 Background | Aug 2022 → Mar 2025 overdue | malaria, pregnancy disorder | Menzies School of Health Research | Active not recruiting | No outcome recorded |
| Phase 3 | NCT04783051 Comparator | May 2021 → Jun 2022 | Plasmodium falciparum malaria | University of Kinshasa | Completed | Met primary |
| Phase 3 | NCT04336189 Comparator | Dec 2020 → Jul 2024 | malaria | Grant Dorsey, M.D, Ph.D. | Completed | No outcome recorded |
| Phase 3 | NCT04149106 Comparator | Jul 2019 → Dec 2022 | Plasmodium falciparum malaria | University Clinical Research Center, Mali | Unknown | No outcome recorded |
| Phase 3 | NCT03009526 Comparator | Jan 2017 → Oct 2018 | Plasmodium falciparum malaria | Kamuzu University of Health Sciences | Completed | No outcome recorded |
| Phase 3 | NCT02163447 Comparator | Jun 2014 → May 2018 | malaria | Grant Dorsey, M.D, Ph.D. | Completed | No outcome recorded |
| Phase 3 | NCT02211729 Background | May 2014 → Dec 2017 | malaria, respiratory tract infectious disorder | London School of Hygiene and Tropical Medicine | Completed | Missed primary |
| Phase 3 | NCT00711906 Comparator | Feb 2009 → Feb 2010 | malaria | Institute of Tropical Medicine, Belgium | Terminated | No outcome recorded |
| Phase 3 | NCT00399074 Comparator | Oct 2006 → Feb 2007 | malaria, sickle cell disease | Makerere University | Completed | No outcome recorded |
| Phase 3 | NCT00330902 Comparator | Jan → Nov 2004 | malaria | London School of Hygiene and Tropical Medicine | Completed | Missed primary |
| Phase 3 | NCT00131235 Comparator | Dec 2003 → Jun 2007 overdue | malaria, sexually transmitted disease | Tampere University | Active not recruiting | Met primary |
| Phase 4 | NCT05323721 Comparator | Jun → Nov 2022 | malaria | Malaria Consortium | Unknown | No outcome recorded |
| Phase 4 | NCT05186363 Comparator | Jan → Jun 2022 | malaria | Malaria Consortium | Unknown | No outcome recorded |
| Phase 4 | NCT04160026 Comparator | Nov 2019 → Jul 2020 | Plasmodium falciparum malaria | Liverpool School of Tropical Medicine | Completed | Met primary |
| Phase 4 | NCT01084213 Comparator | Jun 2010 → Jul 2012 | anemia, malaria, pregnancy disorder | London School of Hygiene and Tropical Medicine | Completed | Met primary |
| Phase 4 | NCT00452907 Comparator | Jul 2005 → Jun 2007 | malaria | Sanofi | Completed | No outcome recorded |
| — | NCT05949190 Background | Aug 2023 → Oct 2026 expected | postpartum depression | Washington University School of Medicine | Active not recruiting | No outcome recorded |
| — | NCT05354258 Background | Jun → Nov 2022 | Nematoda infectious disease, malaria, schistosomiasis | London School of Hygiene and Tropical Medicine | Unknown | No outcome recorded |
| — | NCT03944317 Comparator | Jun → Nov 2019 | malaria, pregnancy disorder | Federal Medical Centre, Owo | Unknown | No outcome recorded |
| — | NCT00857077 Comparator | Sep 2000 → Jun 2004 | anemia, malaria | London School of Hygiene and Tropical Medicine | Completed | No outcome recorded |
Evidence & citations 7 cited values
Every value below carries the sentence it was read from. 68 sources stand behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | sulfadoxine/pyrimethamine | “The efficacy of intermittent preventive treatment for malaria with sulfadoxine-pyrimethamine (IPTp-SP) in pregnancy is threatened in parts of Africa by the emergence and spread...” PMID 26258474 ↗ Aug 201562“It is reasonable to assume that the efficacy of IPTi will be influenced markedly by the sensitivity of Plasmodium falciparum to the antimalarial drug...” NCT00453856 ↗ “Schools were randomly assigned to treatment (sulfadoxine-pyrimethamine in combination with amodiaquine or dual placebo) by use of a computer-generated list.” PMID 18620950 ↗ Jul 2008 “Intermittent Preventive Treatment in pregnancy (IPTp) with sulfadoxine-pyrimethamine (SP) is an important malaria control strategy in sub-Saharan Africa.” PMID 36443882 ↗ Nov 2022 “receive Vitamin A and Zinc on Day 0, followed by SMC drugs (sulfadoxine-pyrimethamine and amodiaquine) on Days 1-3 (control group);” PMID 37957702 ↗ Nov 2023 “Intermittent preventive treatment with sulfadoxine/pyrimethamine (SP) is recommended for malaria prevention in infants (IPTi-SP).” PMID 24038364 ↗ Sep 2011 “Monthly administration of sulfadoxine-pyrimethamine plus amodiaquine, combined with community case management” NCT01449045 ↗ “monthly sulfadoxine-pyrimethamine plus amodiaquine used for seasonal malaria chemoprevention” PMID 30699301 ↗ Jan 2019 “The standard SMC regimen includes sulfadoxine-pyrimethamine (SP) plus amodiaquine (AQ).” PMID 38252481 ↗ Jan 2024 “Sulfadoxine-pyrimethamine paediatric formulation (250mg/12.5mg) dispersable tablets” NCT06166498 ↗ “with Sulfadoxine-Pyrimethamine (SP) against clinical disease” PMID 21767403 ↗ Jul 2011 |
| Known as | Fansidar | “A major part of the study involves administering an effective antimalarial, sulfadoxine-pyrimethamine (Fansidar®), to children at the same timepoints as vaccinations, i.e. at...” NCT00167843 ↗3“Sulfadoxine-Pyrimethamine (Fansidar)” NCT00209781 ↗ “Sulfadoxine-pyrimethamine (Fansidar)” NCT00270530 ↗ “Sulfadoxine-pyrimethamine (Fansidar)” NCT00137553 ↗ |
| Known as | Kamsidar | “SP (Kamsidar) will be supplied by Kampala Pharmaceutical Industries (KPI), Uganda.” NCT04336189 ↗ |
| Known as | sulphadoxine pyrimethamine | “Therefore, it is proposed to study whether monthly chemoprophylaxis with sulphadoxine/pyrimethamine (S/P) given during malaria transmission season can protect Gambian children...” NCT00131716 ↗6“The World Health Organization (WHO) recommends intermittent preventive treatment in pregnancy (IPTp) with sulphadoxine-pyrimethamine (SP) for pregnant women living in areas of...” PMID 39324693 ↗ Sep 2024 “Intermittent preventive treatment in infants (IPTi) with sulphadoxine-pyrimethamine (SP) for the prevention of malaria has shown promising results in six trials.” PMID 20368815 ↗ Apr 2010 “Intermittent preventive treatment in infants (IPTi) with sulphadoxine-pyrimethamine (SP) reduces the incidence of malaria episodes in young children.” PMID 18828899 ↗ Oct 2008 “dihydrofolate reductase (dhfr) and dihydropteroate synthase (dhps) polymorphisms confer resistance to sulphadoxine-pyrimethamine (SP).” PMID 21569596 ↗ May 2011 “with sulphadoxine-pyrimethamine (IPTi-SP) reduced the incidence of malaria and anaemia by 30% and 20% respectively.” PMID 22423611 ↗ Mar 2012 “seasonal IPT with sulphadoxine pyrimethamine (SP) on incidence of malaria disease” PMID 18611271 ↗ Jul 2008 |
| Action | Inhibit | “SP acts by inhibiting parasite enzymes in the metabolism of folic acid.” NCT00130065 ↗ |
| Modality | Small molecule | “Sulphadoxine is a slowly eliminated sulphonamide.” NCT05478954 ↗ |
| Route | Oral | “a single dose of oral SP” NCT00167739 ↗ |