Study of the Impact of Intermittent Preventive Treatment in Schools on Malaria, Anaemia and Education.

Phase 3 Completed 6758 enrolled London School of Hygiene and Tropical Medicine University of Nairobi · collab

RandomizedParallel-groupQuadruple-blindPrevention

Summary

This study seeks to establish whether intermittent preventive treatment (IPT) can reduce malaria among school-going children and its consequent impact on school performance.

Timeline

Start: 2005-01
Primary completion: 2006-04
Completion: 2006-04

Outcome

Met primary endpoint

paper 6.3% in the IPT group and 12.6% in the placebo group (adjusted risk ratio 0.52, 95% CI 0.29-0.93; p=0.028). PMID 18620950 ↗

Publications

Background Clarke SE, Brooker S, Jukes MCH, Njagi JK, Khasakhala L, Otido J, Crudder C, McGlone B, Magnussen P & Estambale BBA. (2006). Randomised controlled trial of intermittent preventive treatment in schoolchildren: Impact on malaria, anaemia & school performance [abstract]. American Journal of Tropical Medicine & Hygiene Suppl 75 (5): 123.
Background Clarke S, Njagi J, Jukes M, Estambale B, Khasakhala L, Ajanga A, Luoba A, Otido J, Ochola S & Magnussen P. (2005). Intermittent preventive treatment in schools: Malaria parasitaemia, anaemia and school performance [abstract]. Acta Tropica, Suppl 95: S133.
Clarke SE, Jukes MC, Njagi JK, Khasakhala L, Cundill B, Otido J, Crudder C, Estambale BB, Brooker S. Effect of intermittent preventive treatment of malaria on health and education in schoolchildren: a cluster-randomised, double-blind, placebo-controlled trial. Lancet. 2008 Jul 12;372(9633):127-138. doi: 10.1016/S0140-6736(08)61034-X.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Sulfadoxine-pyrimethamine	Small molecule	—	Oral
Subject	amodiaquine	Other / unclassified	—	Oral