Heart and Blood Pressure Study: The Effect of Aortic Impedance on Myocardial Relaxation

NCT00204984 ↗

Completed 17 enrolled University of Wisconsin, Madison Scios, Inc. · collab

Non-randomizedSingle-groupOpen-labelBasic science

Summary

Does dilation of blood vessels (vasodilation), which decreases aortic stiffness, have a greater effect on heart myocardium relaxation (diastole) than vasodilation which affects mean pressure equally without improving aortic stiffness?

Timeline

Start: 2005-05
Primary completion: 2006-12-20
Completion: 2006-12-20

Publications

Results Sweitzer NK, Hetzel SJ, Skalski J, Velez M, Eggleston K, Mitchell GF. Left ventricular responses to acute changes in late systolic pressure augmentation in older adults. Am J Hypertens. 2013 Jul;26(7):866-71. doi: 10.1093/ajh/hpt043. Epub 2013 Mar 28.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Hydralazine	Small molecule	—	Oral
Subject	Nesiritide	Protein / enzyme biologic	—	Intravenous

Heart and Blood Pressure Study: The Effect of Aortic Impedance on Myocardial Relaxation

Summary

Timeline

Publications

Drugs

Indications