Thyroid Medication and Antidepressants for Treating Major Depression

NCT00208702 ↗

Phase 4 Completed 153 enrolled Emory University National Institute of Mental Health (NIMH) · collab

RandomizedSingle-groupDouble-blindTreatment

Summary

This study will evaluate the effectiveness of treatment with supplemental triiodothyronine (T3, Cytomel) and sertraline (Zoloft), a selective serotonin reuptake inhibitor (SSRI), in improving symptoms of major depressive disorder (MDD).

Timeline

Start: 1996-09
Primary completion: 2003-07
Completion: 2003-07

Outcome

Missed primary endpoint

paper The combination of triiodothyronine (T3) and sertraline is not superior to sertraline monotherapy in the treatment of major depressive disorder. PMID 22964160 ↗

Publications

Results Garlow SJ, Dunlop BW, Ninan PT, Nemeroff CB. The combination of triiodothyronine (T3) and sertraline is not superior to sertraline monotherapy in the treatment of major depressive disorder. J Psychiatr Res. 2012 Nov;46(11):1406-13. doi: 10.1016/j.jpsychires.2012.08.009. Epub 2012 Sep 7.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Sertraline	Small molecule	—	—
Subject	triiodothyronine	Unknown	50 ug	—