drugset / Trial / NCT00215280
Epidemiology and Control of Mansonella Perstans Infection in Uganda
Completed
1000 enrolled
DBL -Institute for Health Research and Development
Ministry of Health, Uganda · collab
RandomizedSingle-groupDouble-blindTreatment
Summary
Mansonella perstans (M. perstans) infection is widespread in Uganda. Knowledge about the epidemiology of this infection, and of the morbidity it induces is poor, and no effective treatment is available. The study aims at providing data on diagnostic, epidemiological, morbidity and treatment aspects of M. perstans infections in Uganda.
Timeline
- Start
- 2005-11
- Primary completion
- —
- Completion
- 2006-02
Publications
- Asio SM, Simonsen PE, Onapa AW. A randomised, double-blind field trial of ivermectin alone and in combination with albendazole for the treatment of Mansonella perstans infections in Uganda. Trans R Soc Trop Med Hyg. 2009 Mar;103(3):274-9. doi: 10.1016/j.trstmh.2008.10.038. Epub 2008 Dec 9.
- Asio SM, Simonsen PE, Onapa AW. Mansonella perstans filariasis in Uganda: patterns of microfilaraemia and clinical manifestations in two endemic communities. Trans R Soc Trop Med Hyg. 2009 Mar;103(3):266-73. doi: 10.1016/j.trstmh.2008.08.007. Epub 2008 Sep 21.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Albendazole | Small molecule | 400 mg | — |
| Subject | Ivermectin | Small molecule | 150 ug/kg | — |
| Subject | Ivermectin | Small molecule | 200 ug/kg | — |