Drugs / Albendazole
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Albendazole

Small molecule

Developed for
filariasis · helminthiasis · hookworm infectious disease · trichuriasis · anemia · intestinal helminthiasis · ascariasis · cysticercosis
+34 more · malaria · Nematoda infectious disease · onchocerciasis · protein-energy malnutrition · tuberculosis · alveolar echinococcosis · cholera · chronic diarrheal disease · clonorchiasis · COVID-19 · enterocolitis · epilepsy · gas bloat syndrome · intestinal schistosomiasis · kwashiorkor · loiasis · mansonelliasis · marasmus · necatoriasis · neoplasm · parasitic infectious disease · parasitic intestinal disorder · Plasmodium falciparum malaria · protozoa infectious disease · strongyloidiasis · toxocariasis · typhoid fever · visceral leishmaniasis · coinfection · cystic echinococcosis · diarrheal disease · eosinophil disorder · intestinal disorder · ocular onchocerciasis
Investigated by
London School of Hygiene and Tropical Medicine · Washington University School of Medicine · Jennifer Keiser · Fundación Mundo Sano · Kenya Medical Research Institute · National Institute of Allergy and Infectious Diseases (NIAID)
+110 more · Public Health Laboratory Ivo de Carneri · Swiss Tropical & Public Health Institute · Universidad Nacional de Salta · University Ghent · University Hospitals Cleveland Medical Center · DBL -Institute for Health Research and Development · European Union · International Centre for Diarrhoeal Disease Research, Bangladesh · University of Washington · Bill and Melinda Gates Foundation · Centre Suisse de Recherches Scientifiques en Cote d'Ivoire · Centre d'Appui à la lutte contre la Maladie · Emory University · Ghana Health Services · Imperial College London · Ministry of Health, Uganda · National Institute for Medical Research, Tanzania · Research Institute for Development · United States Agency for International Development (USAID) · University of Cambridge · University of Malawi · Wellcome Trust · World Health Organization · ANRS, Emerging Infectious Diseases · AbbVie · Access to Advanced Health Institute (AAHI) · Akeso Associates · Albert B. Sabin Vaccine Institute · Alejandro Krolewiecki · Armauer Hansen Research Institute, Ethiopia · Barcelona Institute for Global Health · Blantyre Institute for Community Ophthalmology (BICO) · Boston Medical Center · Bridges to Development · Brock University · CIVETAN CONICET, Facultad de Ciencias Veterinarias, UNCPBA. Tandil · CIVETAN-Tandil, UNCPBA · Catholic University of Health and Allied Sciences · Centers for Disease Control and Prevention · Centre Hospitalier Universitaire de Besancon · Centre de Recherche Médicale de Lambaréné · Chengdu Maternal and Children's Health Care Hospital · Christian Medical College, Vellore, India · Commonwealth Scientific and Industrial Research Organisation, Division of Livestock Industries, Brisbane, Australia · Department for International Development, United Kingdom · Department of Science and Technology, Ho Chi Minh City, Viet Nam · Dow University of Health Sciences · Dr. Frank Arguello Cancer Clinic · Drugs for Neglected Diseases · Eastern Congo Initiative · European and Developing Countries Clinical Trials Partnership (EDCTP) · Federal Minstry of Health of Ethiopia · Fight AIDS and Infectious Diseases Foundation · First Affiliated Hospital of Guangxi Medical University · George Washington University · Guangxi Zhuang Autonomous Region Center for Disease Prevention and Control · Göteborg University · HEAL Hospital, DRC · Indian Council of Medical Research · Institut de Recherche Clinique du Benin · Instituto de Ciencia y Medicina Genomica, Torreon, Coah. Mexico www.institutodeciencia.com · Insud Pharma · International Trachoma Initiative · Jawaharlal Institute of Postgraduate Medical Education & Research · Johns Hopkins University · Kamuzu University of Health Sciences · Kenya Ministry of Health · Kenyatta National Hospital · King George's Medical University · Kintampo Health Research Centre, Ghana · Lihir Medical Centre · Makerere University · Malaria Research and Training Center, Bamako, Mali · McGill University Health Centre/Research Institute of the McGill University Health Centre · all 116 on the full record

Regulatory milestones approvals, filings & regulatory actions · 1 recorded

MilestoneJurisdictionBrandIndicationDateSentence it was read from
Approved US (FDA) ALBENZA — 1996-06-11 fda.gov ↗

Trials 73 · started per year

today
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PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 11 trial
Phase 1 NCT03192449 Nov → Dec 2016 helminthiasis Universidad Nacional de Salta Completed No outcome recorded
Phase 1/21 trial
Phase 1/2 NCT01019083 Feb 2008 → Dec 2010 cholera, typhoid fever International Centre for Diarrhoeal Disease Research, Bangladesh Completed No outcome recorded
Phase 211 trials · 2 met primary
Phase 2 NCT03950037 Jan 2022 → Apr 2023 cysticercosis Oregon Health and Science University Withdrawn No outcome recorded
Phase 2 NCT05017194 Aug → Dec 2021 hookworm infectious disease, trichuriasis Jennifer Keiser Completed No outcome recorded
Phase 2 NCT04913610 May 2021 → Aug 2023 onchocerciasis AbbVie Terminated No outcome recorded Stop: Business
Phase 2 NCT04041453 Oct 2019 → Mar 2020 trichuriasis Alejandro Krolewiecki Completed No outcome recorded
Phase 2 NCT03527745 Oct 2018 → Apr 2019 hookworm infectious disease, trichuriasis Jennifer Keiser Completed No outcome recorded
Phase 2 NCT03664063 Sep → Oct 2018 filariasis, yaws Lihir Medical Centre Completed Met primary
Phase 2 NCT03501251 Jul → Aug 2018 trichuriasis Swiss Tropical & Public Health Institute Completed No outcome recorded
Phase 2 NCT01975441 May 2014 → Dec 2017 filariasis University Hospitals Cleveland Medical Center Completed Met primary
Phase 2 NCT02366884 Jul 2011 → Dec 2022 neoplasm Dr. Frank Arguello Cancer Clinic Unknown No outcome recorded
Phase 2 NCT00375583 Sep 2006 → Apr 2011 filariasis National Institute of Allergy and Infectious Diseases (NIAID) Completed No outcome recorded
Phase 2/32 trials · 1 missed
Phase 2/3 NCT05283954 May → Jun 2022 COVID-19 Oriol Mitja Withdrawn No outcome recorded Stop: Business
Phase 2/3 NCT04700423 Mar → Aug 2021 ascariasis, hookworm infectious disease, intestinal helminthiasis, trichuriasis Jennifer Keiser Completed Missed primary
Phase 312 trials · 1 met primary · 2 missed
Phase 3 NCT06282315 Sep 2025 → Apr 2026 overdue intestinal helminthiasis Insud Pharma Recruiting No outcome recorded
Phase 3 NCT06613997 Jan 2025 → Dec 2026 expected loiasis Programme National de Lutte contre l'Onchocercose, Republic of the Congo Not yet recruiting No outcome recorded
Phase 3 NCT06188715 May → Aug 2024 ascariasis, hookworm infectious disease, trichuriasis Jennifer Keiser Completed Met primary
Phase 3 NCT04738812 Apr 2022 → Nov 2025 HIV infectious disease, immunodeficiency disease, tuberculosis ANRS, Emerging Infectious Diseases Completed No outcome recorded
Phase 3 NCT04726969 Jun → Sep 2021 ascariasis, hookworm infectious disease, trichuriasis Jennifer Keiser Completed Missed primary
Phase 3 NCT03014167 Oct 2017 → Jul 2024 filariasis University of Washington Completed Mixed
Phase 3 NCT02078024 Jun 2014 → Jun 2018 onchocerciasis University Hospitals Cleveland Medical Center Completed No outcome recorded
Phase 3 NCT01825031 Jun 2013 → Mar 2016 HIV infectious disease Medical Research Council Completed Missed primary
Phase 3 NCT03238131 Apr 2012 → Apr 2015 onchocerciasis University Hospitals Cleveland Medical Center Completed No outcome recorded
Phase 3 NCT00396500 Apr 1994 → Dec 1996 helminthiasis, nutritional deficiency disease King George's Medical University Completed No outcome recorded
Phase 416 trials · 4 met primary · 2 missed
Phase 4 NCT06376396 Jun 2024 → Dec 2025 overdue cysticercosis R-Evolution Worldwide S.r.l. Impresa Sociale Not yet recruiting No outcome recorded
Phase 4 NCT03570814 Dec 2021 → Feb 2022 filariasis, trachoma London School of Hygiene and Tropical Medicine Completed Met primary
Phase 4 NCT04326868 Nov 2019 → Dec 2020 helminthiasis Centre de Recherche Médicale de Lambaréné Completed No outcome recorded
Phase 4 NCT03278431 Sep → Nov 2017 hookworm infectious disease Swiss Tropical & Public Health Institute Completed Met primary
Phase 4 NCT03036059 May 2017 → Dec 2019 filariasis Noguchi Memorial Institute for Medical Research Completed No outcome recorded
Phase 4 NCT03032042 Jan → Feb 2017 helminthiasis University of California, San Francisco Withdrawn No outcome recorded
Phase 4 NCT02397772 Mar 2015 → Jun 2017 Nematoda infectious disease London School of Hygiene and Tropical Medicine Completed Met primary
Phase 4 NCT01748929 Feb 2014 → Feb 2015 parasitic intestinal disorder McGill University Health Centre/Research Institute of the McGill University Health Centre Completed Missed primary
Phase 4 NCT01903057 Feb → Mar 2014 filariasis, trachoma Emory University Withdrawn No outcome recorded
Phase 4 NCT02675140 Mar 2012 → Sep 2014 anemia, hookworm infectious disease Chengdu Maternal and Children's Health Care Hospital Completed No outcome recorded
Phase not applicable30 trials · 1 met primary · 4 missed
— NCT07074444 Jul 2025 → Feb 2027 expected clonorchiasis First Affiliated Hospital of Guangxi Medical University Recruiting No outcome recorded
— NCT06182176 May → Nov 2024 Nematoda infectious disease, malaria, schistosomiasis London School of Hygiene and Tropical Medicine Unknown No outcome recorded
— NCT05453045 Jul → Aug 2022 — Universidad Nacional de Salta Unknown No outcome recorded
— NCT05354258 Jun → Nov 2022 Nematoda infectious disease, malaria, schistosomiasis London School of Hygiene and Tropical Medicine Unknown No outcome recorded
— NCT05208333 May 2022 → Dec 2023 toxocariasis Pham Ngoc Thach University of Medicine Unknown No outcome recorded
— NCT04041427 Jul → Sep 2019 helminthiasis Universidad Nacional de Salta Completed No outcome recorded
— NCT03598842 Jul 2019 → Dec 2025 helminthiasis, protein-energy malnutrition, tuberculosis Boston Medical Center Completed No outcome recorded
— NCT03155035 Mar → Jun 2017 helminthiasis Dow University of Health Sciences Completed No outcome recorded
— NCT03465488 Aug 2016 → Jan 2018 intestinal helminthiasis University Ghent Completed No outcome recorded
— NCT02974049 Jan 2015 → Sep 2018 filariasis University Hospitals Cleveland Medical Center Completed Missed primary
Comparator or background therapy60 trials
Phase 1 NCT02845713 Comparator Apr → Jun 2016 filariasis University Hospitals Cleveland Medical Center Completed No outcome recorded
Phase 2 NCT07258173 Comparator May → Sep 2026 overdue trichuriasis Jennifer Keiser Not yet recruiting No outcome recorded
Phase 2 NCT07045493 Comparator Jul 2025 → Mar 2026 overdue intestinal helminthiasis International Centre for Diarrhoeal Disease Research, Bangladesh Enrolling by invitation No outcome recorded
Phase 2 NCT04713787 Comparator Sep 2024 → Jan 2026 overdue trichuriasis Asociacion Benefica Prisma Recruiting No outcome recorded
Phase 2 NCT03435718 Comparator Jul 2024 → Jul 2026 overdue trichuriasis Oxfendazole Development Group Not yet recruiting No outcome recorded

News releases announcing trial results or a regulatory action · 2

DateIssuerRelease
2022-12-21 Medicines Development for Global Health Results American Society of Tropical Medicine and Hygiene Annual Meeting medicinesdevelopment.com ↗
They also note that moxidectin plus albendazole efficacy at 12 months is similar to ivermectin plus albendazole and diethylcarbamazine (IDA) and moxidectin plus albendazole and diethylcarbamazine (MoxDA) combinations.
2021-12-18 Medicines Development for Global Health Results MDGH Update - December 2021 medicinesdevelopment.com ↗
Although the data are preliminary and the analysis was of a small subset of the study population, moxidectin combination therapies were well tolerated and the efficacy observed warrants further evaluation.

All press releases naming this drug 4 releases

DateIssuerRelease

Evidence & citations 18 cited values

Every value below carries the sentence it was read from. 137 sources stand behind the page.

FieldValueCited text
Known as albendazole “The intervention drugs are standard drugs approved by the World Health Organisation for the preventive treatment of malaria (sulphadoxine-pyrimethamine and amodiaquine),...” NCT06182176 ↗
133

“Participants were randomly assigned to one of three treatment arms. On the first and third days, all participants got albendazole 400 mg, and on the second day, albendazole...” PMID 38563751 ↗ Apr 2024

“World Health Organization Pre-Qualification (WHO PQ) recommended ivermectin 3mg tablets will be used together with albendazole 400mg tablets as provided by WHO for Neglected...” NCT06037876 ↗

“Study participants will be given anti-parasitic medications per Indian guidelines such as albendazole, ivermectin, metronidazole, or other medications to treat their parasitic...” NCT03598842 ↗

“evaluating the urine and serum pharmacokinetics of ALBENDAZOLE (ABZ) and its metabolites across a variety of food/fast conditions, age, gender and body weight.” NCT04041427 ↗

“Albendazole single 400mg dose will be given for infection with Ascaris lumbricoides, Ancylostoma duodenale, Necator americanus, Trichuris trichiura.” NCT05323396 ↗

“Lymphatic Filariasis Mass Drug Administration (MDA) with triple drug therapy of ivermectin, diethylcarbamazine, and albendazole (IDA).” NCT03177993 ↗

“receive emodepside, at a single oral dose of 5, 10, 15, 20, 25, or 30 mg; albendazole, at a single oral dose of 400 mg; or placebo” PMID 37195942 ↗ May 2023

“fixed dose combination (FDC) of albendazole (ALB) and ivermectin (IVM) as a single dose to treat Soil-Transmitted Helminths (STH)” NCT06282315 ↗

“all individuals over 1 year receive albendazole and those infected with tungiasis receive benzyl benzoate.” PMID 40480665 ↗ Jun 2025

“Nitazoxanide, Chloroquine, Albendazole, Ivermectin, Mebendazole, Metronidazole, Praziquantel, Levamisole” NCT02366884 ↗

Show 123 more sources

Known as 5-(prophylthio)-2-benzimidazole carbamate “Albendazole, 5-(prophylthio)-2-benzimidazole carbamate, is a broad-spectrum benzimidazole antihelminthic drug.” NCT04713787 ↗
Known as ABZ “Purpose: To assess the efficacy of three proposed anthelminthic combination regimens for the treatment of strongyloidiasis using real-time polymerase chain reaction (real-time...” PMID 41364144 ↗ Dec 2025
2

“evaluating the urine and serum pharmacokinetics of ALBENDAZOLE (ABZ) and its metabolites across a variety of food/fast conditions, age, gender and body weight.” NCT04041427 ↗

“Albendazole (ABZ) 400 mg” NCT04410406 ↗

Known as ALB “This randomised, controlled, double-blinded clinical study investigates the safety and efficacy of albendazole (ALB), mebendazole (MBD) and ivermectin (IVM) separately, and ALB...” NCT01050452 ↗
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“BACKGROUND: Albendazole (ALB) is administered annually to millions of children through global deworming programs targeting soil-transmitted helminths (STHs: Ascaris...” PMID 34665810 ↗ Oct 2021

“Both groups will be treated with a single oral administration of Diethylcarbamazine (DEC) 6 mg/kg + Albendazole (ALB) 400 mg + Ivermectin (IVR) 200 µg/kg (IDA).” NCT02845713 ↗

“fixed dose combination (FDC) of albendazole (ALB) and ivermectin (IVM) as a single dose to treat Soil-Transmitted Helminths (STH)” NCT06282315 ↗

“Participants will be given a dose of oral Ivermectin (IVM) (150 µg/kg) plus Albendazole (ALB) (400 mg)” NCT06070116 ↗

“Ivermectin (IVM) and albendazole (ALB) are administered in areas where onchocerciasis is co-endemic;” NCT02899936 ↗

“FDC of Ivermectin (IVM) and ALB either at single or 3- day regimens” NCT05124691 ↗

“single dose albendazole (ALB) in school age children” NCT01327469 ↗

“Ivermectim (IVM) plus Albendazole (ALB)” NCT02078024 ↗

Known as Albendazol ChEMBL registry synonym — accepted as the source's own label CHEMBL1483 ↗
Known as Albendazolum ChEMBL registry synonym — accepted as the source's own label CHEMBL1483 ↗
Known as Albenza ChEMBL registry synonym — accepted as the source's own label CHEMBL1483 ↗
Known as Andazol ChEMBL registry synonym — accepted as the source's own label CHEMBL1483 ↗
Known as BENDEX “albendazole, 400 mg, single oral dose, (BENDEX)” NCT02420574 ↗
Known as Eskazole ChEMBL registry synonym — accepted as the source's own label CHEMBL1483 ↗
Known as NSC-220008 ChEMBL registry synonym — accepted as the source's own label CHEMBL1483 ↗
Known as OVIS “albendazole, 400 mg, single-oral dose, (OVIS)” NCT02420574 ↗
Known as SK&F 62979 ChEMBL registry synonym — accepted as the source's own label CHEMBL1483 ↗
Known as Valbazen ChEMBL registry synonym — accepted as the source's own label CHEMBL1483 ↗
Known as Zentel “400 mg of albendazole (Zentel” NCT00396500 ↗
2

“albendazole (ALB), Zentel” NCT02420574 ↗

NCT02675140 ↗

Action Inhibit “Albendazole is thought to inhibit cytoplasmic microtubules in the worm's intestinal tract leading to decreased glucose uptake and depletion of glycogen stores in the worm.” NCT00507221 ↗
Modality Small molecule “Albendazole is a benzimidazole carbamate derivative with activity against most nematodes and some other worms.” NCT00507221 ↗
Route Oral “Albendazole and dexamethasone or placebo only is administered orally once daily on days 5-15.” NCT00004403 ↗