drugset / Trial / NCT05017194
Efficacy and Safety of Emodepside in Adults Infected With Trichuris Trichiura and Hookworm
RandomizedParallel-groupSingle-blindTreatment
Summary
The rationale of the study is to provide evidence on the efficacy and safety of Emodepside in adults infected with Trichuris trichiura and hookworm.
Timeline
- Start
- 2021-08-02
- Primary completion
- 2021-12-10
- Completion
- 2021-12-10
Publications
- Montresor A, Gabrielli AF. Emodepside - A Promising Drug for the Treatment of Soil-Transmitted Helminthiases. N Engl J Med. 2023 May 18;388(20):1907-1908. doi: 10.1056/NEJMe2303793. No abstract available.
- Mrimi EC, Welsche S, Ali SM, Hattendorf J, Keiser J. Emodepside for Trichuris trichiura and Hookworm Infection. N Engl J Med. 2023 May 18;388(20):1863-1875. doi: 10.1056/NEJMoa2212825.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Albendazole | Small molecule | 400 mg | Oral |
| Subject | Emodepside | Small molecule | 5 mg | Oral |
| Subject | Emodepside | Small molecule | 10 mg | Oral |
| Subject | Emodepside | Small molecule | 15 mg | Oral |
| Subject | Emodepside | Small molecule | 20 mg | Oral |
| Subject | Emodepside | Small molecule | 25 mg | Oral |
| Subject | Emodepside | Small molecule | 30 mg | Oral |