Combined Package of Interventions for Environmental Enteropathy

Completed 253 enrolled Washington University School of Medicine University of Malawi · collab

RandomizedParallel-groupQuadruple-blindTreatment

Summary

Randomized, double-blind, placebo controlled trial of a combined intervention of zinc, albendazole, and multiple micronutrients in improving environmental enteropathy in Malawian children.

Timeline

Start: 2014-10
Primary completion: 2015-04
Completion: 2015-04

Outcome

Missed primary endpoint

paper After 12 and 24 wk of study, increases in the L:M ratio did not differ between the intervention group PMID 27807040 ↗

paper Relative changes in length and weight also did not differ significantly between groups at any time point. PMID 27807040 ↗

paper The combined usage of albendazole, zinc, and a daily multiple micronutrient powder did not decrease EED or stunting PMID 27807040 ↗

Publications

Wang AZ, Shulman RJ, Crocker AH, Thakwalakwa C, Maleta KM, Devaraj S, Manary MJ, Trehan I. A Combined Intervention of Zinc, Multiple Micronutrients, and Albendazole Does Not Ameliorate Environmental Enteric Dysfunction or Stunting in Rural Malawian Children in a Double-Blind Randomized Controlled Trial. J Nutr. 2017 Jan;147(1):97-103. doi: 10.3945/jn.116.237735. Epub 2016 Nov 2.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Albendazole	Small molecule	—	—