Effectiveness of High-dose Zinc Therapy and Albendazole in the Treatment of Environmental Enteropathy

Completed 225 enrolled Washington University School of Medicine

RandomizedParallel-groupQuadruple-blindTreatment

Summary

The purpose of this study is to investigate the therapeutic effectiveness of high-dose zinc therapy and de-worming albendazole as separate interventions in restoring normal gut absorptive and immunological function as measured by the dual sugar permeability test and additional biomarkers in 1-3 year old rural Malawian children at high risk for Environmental Enteropathy.

Timeline

Start: 2011-10
Primary completion: 2011-12
Completion: 2011-12

Outcome

Met primary endpoint

paper increased more in the placebo group (0.12 ± 0.31) than in the zinc group (0.03 ± 0.20; P < .03) PMID 24462483 ↗

Publications

Ryan KN, Stephenson KB, Trehan I, Shulman RJ, Thakwalakwa C, Murray E, Maleta K, Manary MJ. Zinc or albendazole attenuates the progression of environmental enteropathy: a randomized controlled trial. Clin Gastroenterol Hepatol. 2014 Sep;12(9):1507-13.e1. doi: 10.1016/j.cgh.2014.01.024. Epub 2014 Jan 22.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Albendazole	Small molecule	200 mg	Oral
Subject	Albendazole	Small molecule	400 mg	Oral

Indications

No indication recorded.