Deworming and Enhanced Vitamin A Every 6 Month in Rural Indian Children Aged 1-6

Summary

Randomisation of 72 large rural areas ("blocks") into a 2 x 2 trial of six- monthly treatment of all village children aged 1-5 with albendazole(400mg), vitamin A (200000 iu), both or neither. The placebo group get no trial treatment at all and do not receive physical placebos.

Timeline

Start

1999-01

Primary completion

—

Completion

2005-02

Outcome

Missed primary endpoint

paper mortality ratio 0·95, 95% CI 0·89 to 1·02, p=0·16 PMID 23498850 ↗

paper mortality ratio 0·96, 95% CI 0·89-1·03, p=0·22 PMID 23498849 ↗

Publications

• Awasthi S, Peto R, Read S, Richards SM, Pande V, Bundy D; DEVTA (Deworming and Enhanced Vitamin A) team. Population deworming every 6 months with albendazole in 1 million pre-school children in North India: DEVTA, a cluster-randomised trial. Lancet. 2013 Apr 27;381(9876):1478-86. doi: 10.1016/S0140-6736(12)62126-6. Epub 2013 Mar 14.
• Awasthi S, Peto R, Read S, Clark S, Pande V, Bundy D; DEVTA (Deworming and Enhanced Vitamin A) team. Vitamin A supplementation every 6 months with retinol in 1 million pre-school children in north India: DEVTA, a cluster-randomised trial. Lancet. 2013 Apr 27;381(9876):1469-77. doi: 10.1016/S0140-6736(12)62125-4. Epub 2013 Mar 14.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Albendazole	Small molecule	400 mg	Oral
Subject	Vitamin A	Unknown	200000 iu	Oral

Indications

No indication recorded.