Drugs / Vitamin A
last change Sep 2026 re-read 9 days ago

Vitamin A

Developed for
vitamin A deficiency · diarrheal disease · anemia · bronchopulmonary dysplasia · infectious disease with sepsis · HIV infectious disease · respiratory tract infectious disorder · retinitis pigmentosa
+26 more · acne · central serous chorioretinopathy · colorectal adenoma · COVID-19 · disorder of iron metabolism and transport · dry eye syndrome · intestinal infectious disease · morbid obesity · obstructive sleep apnea syndrome · open-angle glaucoma · pneumonia · preeclampsia · protein-energy malnutrition · pulmonary immaturity · retinopathy of prematurity · skin cancer · swine influenza · trisomy 21 · visceral leishmaniasis · atherosclerosis · graft versus host disease · iron deficiency anemia · latent tuberculosis infection · parasitic intestinal disorder · relapsing-remitting multiple sclerosis · retinal disorder
Investigated by
Bandim Health Project · International Centre for Diarrhoeal Disease Research, Bangladesh · National Institute of Allergy and Infectious Diseases (NIAID) · Chengdu Maternal and Children's Health Care Hospital · Johns Hopkins Bloomberg School of Public Health · Leiden University Medical Center
+51 more · Liaoning Cancer Hospital & Institute · Medical Research Council Unit, The Gambia · National Eye Institute (NEI) · United States Agency for International Development (USAID) · Access to Advanced Health Institute (AAHI) · Aga Khan University · Alcon Research · BASF · Bill and Melinda Gates Foundation · Corporacion Ecuatoriana de Biotecnologia · Dr Cipto Mangunkusumo General Hospital · Erhan Calisici · Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) · First Affiliated Hospital Xi'an Jiaotong University · Harare City Health Department, Harare, Zimbabwe · Huiqing Sun · IRCCS Azienda Ospedaliera Universitaria San Martino - IST Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy · Institute for Human Nutrition, Royal Veterinary School, Copenhagen, Denmark · Institute of Child Health · Ivan FN Hung MD · LILT (Italian league against cancer) · Manchanda Medical Clinic · March of Dimes · McGill University Health Centre/Research Institute of the McGill University Health Centre · NICHD Neonatal Research Network · Nagasaki University · National Center for Research Resources (NCRR) · National Institute of General Medical Sciences (NIGMS) · Pamela Youde Nethersole Eastern Hospital · Prince of Songkla University · Rhode Island Hospital · Rockefeller Foundation · SARA and Linkages Projects, Academy for Educational Development, Washington DC. · Second Affiliated Hospital, School of Medicine, Zhejiang University · Seoul National University Hospital · St. Jude Children's Research Hospital · St. Petersburg State Pavlov Medical University · The Gerber Foundation · Third Military Medical University · Tufts University · University of Athens · University of Montreal · University of Oxford · University of Virginia · University of Washington · University of Zimbabwe · Uppsala University Hospital · West China Hospital · Xi'an Gaoxin Hospital · Xiaodong Zhou · Zhengzhou University

Regulatory milestones approvals, filings & regulatory actions · 1 recorded

MilestoneJurisdictionBrandIndicationDateSentence it was read from
Approved US (FDA) M.V.I.-12 ADULT — 1953-02-20 fda.gov ↗

Trials 43

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 02 trials
Phase 0 NCT05702398 Apr 2023 → Jan 2028 expected disease related to solid organ transplantation, skin cancer Rhode Island Hospital Recruiting No outcome recorded
Phase 0 NCT03090048 Apr → Aug 2021 acne Manchanda Medical Clinic Unknown No outcome recorded
Phase 13 trials
Phase 1 NCT03859687 Aug 2019 → Jul 2025 — St. Jude Children's Research Hospital Terminated No outcome recorded Stop: Enrollment
Phase 1 NCT03117660 Jul 2017 → Oct 2022 — University of Washington Completed No outcome recorded
Phase 1 NCT00065455 Jul 2003 → May 2009 retinitis pigmentosa National Eye Institute (NEI) Completed No outcome recorded
Phase 1/21 trial · 1 met primary
Phase 1/2 NCT01203488 Jan 1996 → Jul 1997 bronchopulmonary dysplasia, fetal growth restriction, infectious disease with sepsis, newborn respiratory distress syndrome NICHD Neonatal Research Network Completed Met primary
Phase 28 trials · 1 missed
Phase 2 NCT06508099 May 2024 → May 2026 overdue acute biphenotypic leukemia, chronic myeloid leukemia, lymphoblastic lymphoma, myelodysplastic syndrome St. Petersburg State Pavlov Medical University Recruiting No outcome recorded
Phase 2 NCT05774964 Mar 2023 → Mar 2025 — Liaoning Cancer Hospital & Institute Unknown No outcome recorded
Phase 2 NCT05720559 Mar 2023 → Mar 2026 overdue — Liaoning Cancer Hospital & Institute Not yet recruiting No outcome recorded
Phase 2 NCT04900415 Jul 2020 → Mar 2021 COVID-19 Ivan FN Hung MD Unknown No outcome recorded
Phase 2 NCT00963131 Dec 2004 → Dec 2008 central serous chorioretinopathy Prince of Songkla University Completed No outcome recorded
Phase 2 NCT00198718 Nov 1997 → May 2001 HIV infectious disease, vitamin A deficiency Johns Hopkins Bloomberg School of Public Health Completed Missed primary
Phase 2 NCT00053612 ? → Jun 2006 HIV infectious disease, vitamin A deficiency National Institute of Allergy and Infectious Diseases (NIAID) Completed No outcome recorded
Phase 2 NCT00133419 ? → Jan 2006 intestinal infectious disease National Institute of Allergy and Infectious Diseases (NIAID) Completed No outcome recorded
Phase 37 trials · 1 missed
Phase 3 NCT03876704 Jan → Sep 2019 anemia, bronchopulmonary dysplasia, infectious disease with sepsis, vitamin A deficiency +1 First Affiliated Hospital Xi'an Jiaotong University Unknown No outcome recorded
Phase 3 NCT07577180 Mar 2012 → Mar 2013 bronchopulmonary dysplasia Erhan Calisici Completed No outcome recorded
Phase 3 NCT01265589 Jan → Dec 2012 — Third Military Medical University Unknown No outcome recorded
Phase 3 NCT00133406 Jun 2006 → Dec 2011 diarrheal disease University of Virginia Unknown No outcome recorded
Phase 3 NCT00116493 Apr 2004 → May 2007 anemia Johns Hopkins Bloomberg School of Public Health Completed Missed primary
Phase 3 NCT01437826 Mar 1988 → Jun 1996 colorectal adenoma IRCCS Azienda Ospedaliera Universitaria San Martino - IST Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy Terminated No outcome recorded
Phase 3 NCT00000114 May 1984 → Jun 1987 retinitis pigmentosa National Eye Institute (NEI) Completed No outcome recorded
Phase 49 trials · 4 missed
Phase 4 NCT02675140 Mar 2012 → Sep 2014 anemia, hookworm infectious disease Chengdu Maternal and Children's Health Care Hospital Completed No outcome recorded
Phase 4 NCT01127282 Dec 2009 → Jun 2010 swine influenza Seoul National University Hospital Unknown No outcome recorded
Phase 4 NCT00168636 Nov 2004 → Nov 2013 morbid obesity Bandim Health Project Completed Missed primary
Phase 4 NCT00168610 Nov 2004 → ? — Bandim Health Project Unknown Missed primary
Phase 4 NCT00168623 Nov 2003 → Dec 2014 — Bandim Health Project Unknown No outcome recorded
Phase 4 NCT00168584 Nov 2002 → Aug 2003 — Bandim Health Project Completed No outcome recorded
Phase 4 NCT00168597 Aug 2002 → Nov 2013 — Bandim Health Project Completed Missed primary
Phase 4 NCT00228254 Jan 2000 → Jun 2004 diarrheal disease, pneumonia Tufts University Completed No outcome recorded
Phase 4 NCT00222547 Jan 1999 → Feb 2005 — University of Oxford Completed Missed primary
Phase not applicable13 trials · 2 missed
— NCT04127968 Nov 2022 → Dec 2023 infectious disease with sepsis, vitamin A deficiency West China Hospital Unknown Missed primary
— NCT04000789 Jul → Dec 2019 dry eye syndrome, proliferative diabetic retinopathy Dr Cipto Mangunkusumo General Hospital Unknown No outcome recorded
— NCT03971604 Jan 2019 → Jan 2022 preeclampsia, vitamin A deficiency Second Affiliated Hospital, School of Medicine, Zhejiang University Unknown No outcome recorded
— NCT03154723 Aug 2015 → Dec 2017 retinopathy of prematurity Huiqing Sun Completed No outcome recorded
— NCT02077231 Sep 2011 → Feb 2013 open-angle glaucoma Xiaodong Zhou Completed No outcome recorded
— NCT01355263 Jul 2011 → Feb 2012 disorder of iron metabolism and transport Chengdu Maternal and Children's Health Care Hospital Completed No outcome recorded
— NCT01188005 Aug → Oct 2010 obstructive sleep apnea syndrome University of Athens Unknown No outcome recorded
— NCT01069198 Oct 2009 → Oct 2010 visceral leishmaniasis International Centre for Diarrhoeal Disease Research, Bangladesh Completed No outcome recorded
— NCT00388921 Oct 2005 → Dec 2007 diarrheal disease, protein-energy malnutrition, respiratory tract infectious disorder International Centre for Diarrhoeal Disease Research, Bangladesh Completed No outcome recorded
— NCT00168649 Jun 2005 → Jun 2014 — Bandim Health Project Unknown No outcome recorded
Comparator or background therapy13 trials
Phase 2 NCT06450925 Comparator Mar 2025 → Aug 2027 expected graft versus host disease, vitamin A deficiency, vitamin D deficiency Children's Hospital Medical Center, Cincinnati Recruiting No outcome recorded
Phase 3 NCT00114868 Comparator Jun 1998 → Apr 2001 — Johns Hopkins Bloomberg School of Public Health Completed No outcome recorded
Phase 3 NCT00396500 Background Apr 1994 → Dec 1996 helminthiasis, nutritional deficiency disease King George's Medical University Completed No outcome recorded
Phase 4 NCT03112382 Comparator Nov 2015 → May 2017 type 2 diabetes mellitus Cairo University Completed No outcome recorded
Phase 4 NCT01414972 Comparator May 2010 → Jan 2011 atherosclerosis Tehran University of Medical Sciences Unknown No outcome recorded

Evidence & citations 5 cited values

Every value below carries the sentence it was read from. 56 sources stand behind the page.

FieldValueCited text
Known as Vitamin A “with daily multivitamins [vitamin A (300 microg, as retinol palmitate), vitamin E (6 mg tocopherol equivalents), vitamin B-12 (0.9 microg), vitamin C (15 mg), riboflavin (0.5...” PMID 19535425 ↗ Jun 2009
55

“Fat-soluble vitamins is administered 0.5 piece/kg (equals to 1150 U/kg vitamin A,200 U/kg vitamin D, 3.2 U/kg vitamin E) intravenously every day until the baby achieve full...” NCT03876704 ↗

“vitamin A 0.9 mg, vitamin E 100 mg” PMID 18296460 ↗ Feb 2008

“2 mg vitamin A \[retinol\]” NCT01437826 ↗

“vitamin A 6600 IU” NCT00963131 ↗

NCT00133419 ↗

NCT00374023 ↗

NCT02077231 ↗

NCT01188005 ↗

NCT03859687 ↗

NCT00388921 ↗

Show 45 more sources

Known as retinol palmitate “with daily multivitamins [vitamin A (300 microg, as retinol palmitate), vitamin E (6 mg tocopherol equivalents), vitamin B-12 (0.9 microg), vitamin C (15 mg), riboflavin (0.5...” PMID 19535425 ↗ Jun 2009
Known as retinyl palmitate “The Vitamin A treatment group will receive 5,000 IU of Vitamin A (retinyl palmitate) by intramuscular injection 3 times weekly for 28 days starting on postnatal day 2.” NCT00063596 ↗
2

“supplementation with 25000 IU preformed vitamin A (retinyl palmitate) or placebo” NCT01414972 ↗

“Vitamin A (retinyl palmitate)” NCT00198718 ↗

Known as vitamin A and E ClinicalTrials.gov intervention name — accepted as the source's own label NCT03112382 ↗
Route Intramuscular “by intramuscular injection” NCT00063596 ↗