Efficacy and Safety of Vitamin A Treatment for Children With Sepsis

Summary

The prevalence of vitamin A deficiency was found high in children with sepsis. Whether those patients will benefit from the vitamin A supplementation is unknown.

Timeline

Start

2022-11-01

Primary completion

2023-12-31

Completion

2024-05-31

Outcome

Missed primary endpoint

paper There was no significant difference in ICU length of stay between the VAS and placebo groups [14 (7-27) vs. 16.5 (9.3-26) days, P = 0.451]. PMID 40843069 ↗

Publications

• Fu Q, Liu M, Zhang X, Fu J, Zhang G, Ji Y, Chen S. A randomized controlled trial on the efficacy and safety of vitamin A supplementation in children with sepsis. Front Pediatr. 2025 Aug 6;13:1579006. doi: 10.3389/fped.2025.1579006. eCollection 2025.

Drugs

Indications