drugset / Trial / NCT03117660
Effects of Retinoids on CYP2D6 Activity During Pregnancy
Phase 1
Completed
82 enrolled
University of Washington
National Institute of General Medical Sciences (NIGMS) · collab
RandomizedParallel-groupOpen-labelBasic science
Summary
Prospective drug interaction study during pregnancy.
Timeline
- Start
- 2017-07-25
- Primary completion
- 2022-10-31
- Completion
- 2022-10-31
Publications
- Background Somani ST, Zeigler M, Fay EE, Leahy M, Bermudez B, Totah RA, Hebert MF. Changes in erythrocyte membrane epoxyeicosatrienoic, dihydroxyeicosatrienoic, and hydroxyeicosatetraenoic acids during pregnancy. Life Sci. 2021 Jan 1;264:118590. doi: 10.1016/j.lfs.2020.118590. Epub 2020 Oct 15.
- Background Amaeze OU, Czuba LC, Yadav AS, Fay EE, LaFrance J, Shum S, Moreni SL, Mao J, Huang W, Isoherranen N, Hebert MF. Impact of Pregnancy and Vitamin A Supplementation on CYP2D6 Activity. J Clin Pharmacol. 2023 Mar;63(3):363-372. doi: 10.1002/jcph.2169. Epub 2022 Nov 15.
- Background Czuba LC, Fay EE, LaFrance J, Smith CK, Shum S, Moreni SL, Mao J, Isoherranen N, Hebert MF. Plasma Retinoid Concentrations Are Altered in Pregnant Women. Nutrients. 2022 Mar 25;14(7):1365. doi: 10.3390/nu14071365.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Vitamin A | Unknown | — | — |
Indications
No indication recorded.