drugset / Trial / NCT05774964
Quintuple Method for Treatment of Multiple Refractory Colorectal Liver Metastases
RandomizedSingle-groupOpen-labelTreatment
Summary
The aim of this study is to explore the therapeutic effect of Quintuple method in the treatment of patients with multiple and refractory liver metastases from colorectal cancer. A randomized single-arm clinical trial was conducted.The intervention group was treated with single SOX chemotherapy, SOX chemotherapy combined with cetuximab targeted therapy, SOX chemotherapy combined with low-dose cetuximab targeted therapy combined with three-drug regimen（Quintuple method）, and the RECIST 1.1 solid tumor evaluation criteria were used to assess the disease.
Timeline
- Start
- 2023-03-15
- Primary completion
- 2025-03-15
- Completion
- 2025-03-15
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Cetuximab | Monoclonal antibody | 250 mg/m2 | Intravenous |
| Subject | Metronidazole | Small molecule | 0.4 g | — |
| Subject | Oxaliplatin | Small molecule | 130 mg/m2 | Intravenous |
| Subject | S-1 | Small molecule | 20 mg | Oral |
| Subject | Vitamin A | Unknown | 5000 iu | — |
| Subject | folic acid | Other / unclassified | 5 mg | — |
Indications
No indication recorded.