drugset / Trial / NCT02078024

Efficacy of Ivermectin and Albendazole Against Onchocerciasis in the Volta Region, Ghana

NCT02078024

Phase 3 Completed 375 enrolled University Hospitals Cleveland Medical Center
RandomizedFactorialOpen-labelDiagnostic

Summary

We will examine whether a combination of Ivermectim (IVM) plus Albendazole (ALB) compared to IVM alone given annually, which is the current standard for mass drug administration (MDA), is more effective in sterilizing adult worms. We will also address whether IVM plus ALB given twice per year is superior to IVM given once per year or twice per year.

Timeline

Start
2014-06
Primary completion
2018-06
Completion
2018-06-25

Drugs

EvaluationDrugModalityDoseRoute
Subject Albendazole Small molecule 400 mg
Subject Albendazole Small molecule 800 mg
Subject Ivermectin Small molecule 200 ug/kg Oral

Indications