drugset / Trial / NCT00218608

Disulfiram for Treating Cocaine Dependence in Individuals Maintained on Methadone

NCT00218608

Phase 2 Completed 158 enrolled University of Arkansas Yale University · collab
RandomizedParallel-groupQuadruple-blindTreatment

Summary

Cocaine is an extremely addictive stimulant drug that directly affects the brain. It is used in several different forms and can be snorted, smoked, or injected to achieve the desired effect. Cocaine users are at risk for many health problems, both directly and indirectly related to the effects of cocaine. Disulfiram, a drug used to treat chronic alcoholism, may be effective in reducing cocaine use. This study will evaluate the effectiveness of three different doses of disulfiram in treating cocaine dependence in opioid- and cocaine-dependent individuals maintained on methadone.

Timeline

Start
2001-04
Primary completion
2007-01
Completion
2007-01

Drugs

EvaluationDrugModalityDoseRoute
Comparator Disulfiram Small molecule 62.5 mg
Comparator Disulfiram Small molecule 125 mg
Comparator Disulfiram Small molecule 250 mg