Xalacom And Combination Of Unfixed Latanoprost And Timolol In Subjects With Open-Angle Glaucoma Or Ocular Hypertension

NCT00219596 ↗

Phase 3 Completed 240 enrolled Viatris Inc.

RandomizedParallel-groupOpen-labelTreatment

Summary

to compare efficacy and safety of Xalacom with the combination of unfixed Latanoprost and Timolol in subjects with open-angel glaucoma or ocular hypertension

Timeline

Start: 2005-06
Primary completion: —
Completion: 2006-09

Outcome

Met primary endpoint

paper between-treatment difference: 0.3 mmHg; 95%-CI, -0.3 to 1.0 PMID 21851642 ↗

Publications

Zhao JL, Ge J, Li XX, Li YM, Sheng YH, Sun NX, Sun XH, Yao K, Zhong Z; Xalacom Study Group in China. Comparative efficacy and safety of the fixed versus unfixed combination of latanoprost and timolol in Chinese patients with open-angle glaucoma or ocular hypertension. BMC Ophthalmol. 2011 Aug 19;11:23. doi: 10.1186/1471-2415-11-23.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Latanoprost	Small molecule	—	—
Subject	Timolol	Other / unclassified	—	—
Subject	Xalacom	Unknown	50 ug/ml	—
Subject	Xalacom	Unknown	0.5 mg/ml	—