Comparison of Oral Iron With IV Iron in Patients With Anemia of Chronic Renal Failure Not on Dialysis

Summary

The purpose of the study was to compare the efficacy of oral iron (ferrous sulfate) plus erythropoietin to Iron Sucrose plus erythropoietin for managing anemia patients with chronic renal failure who are not receiving dialysis.

Timeline

Start

2001-02-23

Primary completion

2002-05-30

Completion

2002-05-30

Outcome

Mixed primary results

paper There was no significant difference in hemoglobin values between IV and oral therapy. PMID 15824508 ↗

paper IV iron patients had greater increases in mean serum ferritin (288 ng/ml, p < 0.0001) compared to oral iron patients (-5.1 ng/ml, p = NS). PMID 15824508 ↗

Publications

• Results Charytan C, Qunibi W, Bailie GR; Venofer Clinical Studies Group. Comparison of intravenous iron sucrose to oral iron in the treatment of anemic patients with chronic kidney disease not on dialysis. Nephron Clin Pract. 2005;100(3):c55-62. doi: 10.1159/000085049. Epub 2005 Apr 11.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Ferrous Sulfate	Diagnostic / imaging agent	325 mg	Oral
Subject	Iron sucrose	Unknown	200 mg	Intravenous
Comparator	epoetin alfa	Protein / enzyme biologic	2000 iu	Subcutaneous

Indications