Topiramate in the Treatment of Pathological Gambling

Phase 3 Terminated 42 enrolled Icahn School of Medicine at Mount Sinai Ortho-McNeil, Inc. · collab

RandomizedParallel-groupDouble-blindTreatment

Summary

This study will assess the efficacy of topiramate in the treatment of pathological gambling. Pathological gambling (PG) is a debilitating disorder, generally leading to severe personal, familial, financial, social, and occupational impairments. In PG, the patient experiences a progressive inability to resist impulses to gamble, and gambling significantly disrupt the patient's functioning in the personal, familial, and/or vocational spheres. Topiramate has shown preliminary evidence of efficacy in some impulse control disorders.

Timeline

Start: 2005-10
Primary completion: 2009-05
Completion: 2009-05

Outcome

Missed primary endpoint

Stopped (Enrollment): “low enrollment”

paper no significant treatment effect of topiramate on the primary or secondary outcome measures. PMID 21486110 ↗

Publications

Results Berlin HA, Braun A, Simeon D, Koran LM, Potenza MN, McElroy SL, Fong T, Pallanti S, Hollander E. A double-blind, placebo-controlled trial of topiramate for pathological gambling. World J Biol Psychiatry. 2013 Mar;14(2):121-8. doi: 10.3109/15622975.2011.560964. Epub 2011 Apr 12.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Topiramate	Small molecule	300 mg	—