Folate Supplementation in Schizophrenia

Summary

This study aims to examine factors potentially contributing to differences in blood folate, homocysteine or B12 levels between schizophrenia patients, to test the hypothesis that low folate is associated with negative symptoms, and to examine the efficacy of folate supplementation for reducing negative symptoms.

Timeline

Start

2003-12

Primary completion

2008-06

Completion

2008-06

Outcome

Missed primary endpoint

paper Folate supplementation did not significantly affect negative symptoms compared to placebo across the entire cohort. PMID 21334854 ↗

Publications

• Results Hill M, Shannahan K, Jasinski S, Macklin EA, Raeke L, Roffman JL, Goff DC. Folate supplementation in schizophrenia: a possible role for MTHFR genotype. Schizophr Res. 2011 Apr;127(1-3):41-5. doi: 10.1016/j.schres.2010.12.006. Epub 2011 Feb 21.

Drugs

Indications