drugset / Trial / NCT00249691
Effectiveness of Topiramate in Treating Cocaine Dependent Individuals - 1
RandomizedParallel-groupQuadruple-blindTreatment
Summary
Although a great amount of research has been conducted to resolve cocaine dependence, an effective treatment has yet to be discovered. Topiramate is a drug that was found to be useful in treating alcohol dependence. The purpose of this study is to determine the effectiveness of topiramate in treating cocaine dependent individuals.
Timeline
- Start
- 2005-10
- Primary completion
- 2011-10
- Completion
- 2012-10
Outcome
Met primary endpoint
paper topiramate was more efficacious than placebo at increasing the weekly proportion of cocaine nonuse days PMID 24132249 ↗
paper 13.3% vs 5.3%, 95% CI for the estimated mean difference, 1.4%-14.6%, P = .02 PMID 24132249 ↗
Publications
- Khalifa NR, Gibbon S, Vollm BA, Cheung NH, McCarthy L. Pharmacological interventions for antisocial personality disorder. Cochrane Database Syst Rev. 2020 Sep 3;9(9):CD007667. doi: 10.1002/14651858.CD007667.pub3.
- Johnson BA, Ait-Daoud N, Wang XQ, Penberthy JK, Javors MA, Seneviratne C, Liu L. Topiramate for the treatment of cocaine addiction: a randomized clinical trial. JAMA Psychiatry. 2013 Dec;70(12):1338-46. doi: 10.1001/jamapsychiatry.2013.2295.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Topiramate | Small molecule | 300 mg | — |