drugset / Trial / NCT00249964
Combination Paclitaxel, Carboplatin and Temozolomide
NaSingle-groupOpen-labelTreatment
Summary
The purpose of this study is to determine the maximum tolerable dose of temozolomide in combination with fixed dose of paclitaxel and carboplatin and to determine the overall tumor response rate with this combination and to determine the duration of response.
Timeline
- Start
- 2003-11
- Primary completion
- 2011-03
- Completion
- 2011-03
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Temozolomide | Small molecule | 75 mg/m2 | — |
| Subject | Temozolomide | Small molecule | 100 mg/m2 | — |
| Subject | Temozolomide | Small molecule | 125 mg/m2 | — |
| Subject | Temozolomide | Small molecule | 150 mg/m2 | — |
| Background | Carboplatin | Small molecule | 5 unknown | Intravenous |
| Background | Paclitaxel | Small molecule | 175 mg/m2 | Intravenous |