Comparison of Aprepitant Versus Gabapentin in the Prevention of Delayed Nausea and Vomiting

Summary

1. To compare the effectiveness of gabapentin (titrated to300mg TID days -2 to 5) with aprepitant (125mg on day 1 and 80mg on days 2 and 3) in the control of delayed nausea and vomiting associated with level 3, 4 or 5 emetogenic chemotherapy in patients who experienced delayed nausea and/or vomiting during their first cycle of chemotherapy. 2. To evaluate and compare the safety profile associated with each anti-emetic regimen. 3. To assess subject satisfaction with anti-emetic therapy.

Timeline

Start

2004-12

Primary completion

2007-09

Completion

2007-09

Drugs

Indications