Ibuprofen Alone and in Combination With Acetaminophen for Treatment of Fever

Phase 4 Completed 60 enrolled Penn State University Children Youth and Family Consortium · collab

RandomizedParallel-groupOpen-labelTreatment

Summary

Currently, when a child has fever either ibuprofen (e.g. Motrin, Advil) or acetaminophen (e.g. Tylenol) is given. Both Ibuprofen and Acetaminophen are approved for over the counter use for treatment of fever by the Food and Drug Administration (FDA). This study hopes to determine whether giving both medications together is better than giving one medication alone for the treatment of fever.

Timeline

Start: 2006-01
Primary completion: 2009-06
Completion: 2009-06

Publications

Paul IM, Sturgis SA, Yang C, Engle L, Watts H, Berlin CM Jr. Efficacy of standard doses of Ibuprofen alone, alternating, and combined with acetaminophen for the treatment of febrile children. Clin Ther. 2010 Dec;32(14):2433-40. doi: 10.1016/j.clinthera.2011.01.006.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Acetaminophen	Small molecule	15 mg/kg	—
Subject	Ibuprofen	Small molecule	10 mg/kg	—

Indications

No indication recorded.