Ibuprofen Alone and in Combination With Acetaminophen for Treatment of Fever

Summary

Currently, when a child has fever either ibuprofen (e.g. Motrin, Advil) or acetaminophen (e.g. Tylenol) is given. Both Ibuprofen and Acetaminophen are approved for over the counter use for treatment of fever by the Food and Drug Administration (FDA). This study hopes to determine whether giving both medications together is better than giving one medication alone for the treatment of fever.

Timeline

Start

2006-01

Primary completion

2009-06

Completion

2009-06

Outcome

Met primary endpoint

paper Differences among temperature curves were significant (P < 0.001; the combined and alternating arms had significantly better antipyresis PMID 21353111 ↗

paper better antipyresis compared with the ibuprofen-alone group at hours 4 to 6 PMID 21353111 ↗

Publications

• Paul IM, Sturgis SA, Yang C, Engle L, Watts H, Berlin CM Jr. Efficacy of standard doses of Ibuprofen alone, alternating, and combined with acetaminophen for the treatment of febrile children. Clin Ther. 2010 Dec;32(14):2433-40. doi: 10.1016/j.clinthera.2011.01.006.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Acetaminophen	Small molecule	15 mg/kg	—
Subject	Ibuprofen	Small molecule	10 mg/kg	—

Indications

No indication recorded.