Evolution of Analgesic Tolerance With Opioids

Summary

The purpose of this study is to determine the extent to which analgesic tolerance develops in chronic pain patients who are either started on opioids or who receive an increase in pre-study opioid dose level and then observed during long-term (20 weeks) stable opioid therapy. In addition to clinical measures of relief of ongoing chronic pain, estimation of tolerance development will be supplemented by periodic assessment of the anti-nociceptive effects of opioids using the brief thermal sensitization model.

Timeline

Start

2001-03

Primary completion

2004-10

Completion

2005-12

Publications

• Rowbotham MC, Wallace M. Evolution of Analgesic Tolerance and Opioid-Induced Hyperalgesia Over 6 Months: Double-Blind Randomized Trial Incorporating Experimental Pain Models. J Pain. 2020 Sep-Oct;21(9-10):1031-1046. doi: 10.1016/j.jpain.2020.01.005. Epub 2020 Feb 1.

Drugs

Indications