Combination Chemotherapy in Treating Young Patients With Langerhans Cell Histiocytosis

Summary

RATIONALE: Drugs used in chemotherapy work in different ways to stop the growth of Langerhans cell histiocytosis, either by killing the cells or by stopping them from dividing. Giving more than one drug (combination chemotherapy) may be an effective treatment for Langerhans cell histiocytosis. PURPOSE: This randomized clinical trial is studying combination chemotherapy to see how well it works in treating young patients with Langerhans cell histiocytosis.

Timeline

Start

2001-04

Primary completion

—

Completion

2013-06

Publications

• Astigarraga I, Arnardottir H, Abla O, Arico M, Braier J, Donadieu J, Grois N, Henter JI, Ladisch S, Lehrnbecher T, McClain K, Nanduri V, Rodriguez-Galindo C, Sieni E, Weitzman S, Potschger U, Minkov M. Disease extent, not lesion location, determines relapse risk in single-system skeletal Langerhans cell histiocytosis. Blood Adv. 2026 Jul 14;10(13):4776-4785. doi: 10.1182/bloodadvances.2026020075.
• Gadner H, Minkov M, Grois N, Potschger U, Thiem E, Arico M, Astigarraga I, Braier J, Donadieu J, Henter JI, Janka-Schaub G, McClain KL, Weitzman S, Windebank K, Ladisch S; Histiocyte Society. Therapy prolongation improves outcome in multisystem Langerhans cell histiocytosis. Blood. 2013 Jun 20;121(25):5006-14. doi: 10.1182/blood-2012-09-455774. Epub 2013 Apr 15.

Drugs

Indications