Topiramate for the Prophylactic Treatment of Cyclic Vomiting Syndrome in Children

Phase 4 Terminated 12 enrolled Monarch Medical Research Ortho-McNeil Neurologics, Inc. · collab

Non-randomizedSingle-groupOpen-labelPrevention

Summary

The purpose of this study is to assess the effectiveness, tolerability and safety of oral topiramate for the preventative management of Cyclic Vomiting Syndrome. It is believed that topiramate will decrease the frequency, duration and severity of attacks experienced by children and adolescents with Cyclic Vomiting Syndrome.

Timeline

Start: 2006-03
Primary completion: 2007-05
Completion: 2007-06

Publications

Background CULLEN KJ, MA CDONALD WB. The periodic syndrome: its nature and prevalence. Med J Aust. 1963 Aug 3;50(2):167-73. No abstract available.
Background Abu-Arafeh I, Russell G. Prevalence and clinical features of abdominal migraine compared with those of migraine headache. Arch Dis Child. 1995 May;72(5):413-7. doi: 10.1136/adc.72.5.413.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Topiramate	Small molecule	—	Oral

Indications

No indication recorded.