Ambien CR For Treatment Of Insomnia Associated With Depression When Used Concomitantly With Lexapro

Summary

To demonstrate overall improvement of insomnia in subjects treated with zolpidem tartrate extended-release (Ambien CR) and escitalopram (Lexapro) vs. subjects treated with placebo and escitalopram at 2 months.

Timeline

Start

2006-02

Primary completion

2007-06

Completion

—

Outcome

Met primary endpoint

paper Throughout phase 1, zolpidem extended-release led to significantly greater improvements in total sleep time (P < .0001) PMID 21208597 ↗

Publications

• Fava M, Asnis GM, Shrivastava RK, Lydiard B, Bastani B, Sheehan DV, Roth T. Improved insomnia symptoms and sleep-related next-day functioning in patients with comorbid major depressive disorder and insomnia following concomitant zolpidem extended-release 12.5 mg and escitalopram treatment: a randomized controlled trial. J Clin Psychiatry. 2011 Jul;72(7):914-28. doi: 10.4088/JCP.09m05571gry. Epub 2010 Dec 28.

Drugs

Indications