To Determine The Amount Of Voriconazole In The Brain After 2 Loading Doses And 3 Maintenance Doses Over 3 Days

Phase 4 Completed 12 enrolled Pfizer McLean Hospital. Belmont, MA. · collab

Non-randomizedSingle-groupOpen-labelBasic science

Summary

To determine the amount of voriconazole in the brain after 2 loading doses and 3 maintenance doses over 3 days and compare it to the amount of voriconazole in the plasma.

Timeline

Start: 2007-03
Primary completion: 2008-08
Completion: 2008-08

Publications

Henry ME, Bolo NR, Zuo CS, Villafuerte RA, Cayetano K, Glue P, Damle BD, Andrews E, Lauriat TL, Rana NS, Churchill JH, Renshaw PF. Quantification of brain voriconazole levels in healthy adults using fluorine magnetic resonance spectroscopy. Antimicrob Agents Chemother. 2013 Nov;57(11):5271-6. doi: 10.1128/AAC.00394-13. Epub 2013 Aug 12.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Voriconazole	Small molecule	200 mg	Oral

To Determine The Amount Of Voriconazole In The Brain After 2 Loading Doses And 3 Maintenance Doses Over 3 Days

Summary

Timeline

Publications

Drugs

Indications