Drugs / Voriconazole
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Voriconazole

Small molecule targets CYP2B6, CYP2C19, CYP3A4 via inhibition

Developed for
fungal infectious disease · aspergillosis · invasive aspergillosis · candidiasis · infectious disease · acute myeloid leukemia · allergic bronchopulmonary aspergillosis · candidemia
+23 more · myelodysplastic syndrome · corneal ulcer · fungal keratitis · fusariosis · blastomycosis · cancer · chronic obstructive pulmonary disease · Cryptococcal meningitis · cryptococcosis · cutaneous leishmaniasis · cystic fibrosis · immunodeficiency disease · neoplasm · opportunistic mycosis · penicilliosis · pityriasis versicolor · systemic mycosis · acute leukemia · dermatophytosis · fungal infection of eye · neuroaspergillosis · osteomyelitis · pulmonary aspergilloma
Investigated by
Pfizer · National Cancer Institute (NCI) · National Heart, Lung, and Blood Institute (NHLBI) · National Institute of Allergy and Infectious Diseases (NIAID) · Seoul National University Hospital · TFF Pharmaceuticals, Inc.
+105 more · Aravind Eye Hospitals, India · Blood and Marrow Transplant Clinical Trials Network · M.D. Anderson Cancer Center · Medical University of Vienna · Post Graduate Institute of Medical Education and Research, Chandigarh · University of California, San Francisco · Aarhus University Hospital · Abdul Wali Khan University Mardan · Academic Medical Center - University of Amsterdam · Amsterdam UMC, location VUmc · Astellas Pharma Global Development, Inc. · Astellas Pharma Inc · AstraZeneca · BeiGene · Beijing Union Pharmaceutical Factory Ltd · Boehringer Ingelheim · Bristol-Myers Squibb · Brynn Chappell · Chong Kun Dang Pharmaceutical · Cipla Ltd. · Dartmouth-Hitchcock Medical Center · Dr. Frank Arguello Cancer Clinic · Erasmus Medical Center · Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) · European Organisation for Research and Treatment of Cancer - EORTC · European Society for Blood and Marrow Transplantation · Federal University of Rio de Janeiro · First Affiliated Hospital of Guangxi Medical University · First Affiliated Hospital of Zhejiang University · First People's Hospital of Hangzhou · Gilead Sciences · Guangxi Medical University · Guilin Medical College · Haga Hospital · Indiana University · Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Oncology (DGHO) · Instituto de Ciencia y Medicina Genomica, Torreon, Coah. Mexico www.institutodeciencia.com · Instituto de Investigación Hospital Universitario La Paz · Jan-Willem C Alffenaar · Janssen Research & Development, LLC · Johns Hopkins University · Jonsson Comprehensive Cancer Center · Kenneth Hargreaves · Klinikum Oldenburg gGmbH · L.V. Prasad Eye Institute · Lakefront Biotherapeutics NV · Leiden University Medical Center · Manjunath Prakash Pai · Martin-Luther-University Halle-Wittenberg · Masonic Cancer Center, University of Minnesota · McLean Hospital. Belmont, MA. · Mclean Hospital · Meander Medical Center · Medical College of Wisconsin · Min Kyu Park · Nanning Second People's Hospital · National Eye Institute (NEI) · National Institute of General Medical Sciences (NIGMS) · National Institutes of Health (NIH) · National Institutes of Health Clinical Center (CC) · National Marrow Donor Program · Ningbo People's Hospital · OHSU Knight Cancer Institute · OrsoBio, Inc · PETHEMA Foundation · Phillip Brian Smith · Red Cross Hospital, Hangzhou, China · Rennes University Hospital · Samyang Biopharmaceuticals Corporation · San Antonio Military Medical Center · Sara Botros · Scynexis, Inc. · Second Affiliated Hospital of Guangzhou Medical University · Second People's Hospital of Hangzhou · all 111 on the full record

Regulatory milestones approvals, filings & regulatory actions · 4 recorded

MilestoneJurisdictionBrandIndicationDateSentence it was read from
Label expansions (2) US (FDA) VFEND 2004-12-21 – 2019-01-29 fda.gov
Approved US (FDA) VFEND 2002-05-24 fda.gov
Approved EU (EMA) Vfend 2002-03-19 europa.eu

Trials 98 · started per year

today
EU approved 2002
US approved 2002
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19971998199920002001200220032004200520062007200820092010201120122013201420152016201720182019202020212022202320242025202620272028
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 01 trial
Phase 0 NCT04072640 Jan 2021 → Jul 2022 Cryptococcal meningitis, HIV infectious disease First Affiliated Hospital of Zhejiang University Unknown No outcome recorded
Phase 126 trials
Phase 1 NCT07426042 Apr → May 2026 overdue Min Kyu Park Not yet recruiting No outcome recorded
Phase 1 NCT07457203 Apr → May 2026 overdue Beijing Union Pharmaceutical Factory Ltd Not yet recruiting No outcome recorded
Phase 1 NCT06493409 Aug → Dec 2024 Bristol-Myers Squibb Completed No outcome recorded
Phase 1 NCT05822544 Apr 2023 → Feb 2026 overdue obesity disorder, type 2 diabetes mellitus OrsoBio, Inc Recruiting No outcome recorded
Phase 1 NCT05458102 Aug 2022 → May 2023 HIV infectious disease Gilead Sciences Terminated No outcome recorded
Phase 1 NCT05264142 Apr 2022 → Mar 2023 University Hospital, Geneva Unknown No outcome recorded
Phase 1 NCT04865419 Jun 2021 → Aug 2023 hematopoietic and lymphoid cell neoplasm AstraZeneca Terminated No outcome recorded
Phase 1 NCT04551963 Nov 2020 → Feb 2022 B-cell neoplasm BeiGene Completed No outcome recorded
Phase 1 NCT04576325 Nov 2020 → Nov 2021 asthma TFF Pharmaceuticals, Inc. Completed No outcome recorded
Phase 1 NCT05330000 May → Jul 2020 The Affiliated Hospital of Qingdao University Completed No outcome recorded
Phase 1/23 trials
Phase 1/2 NCT02014558 Oct 2013 → Aug 2017 acute myeloid leukemia Astellas Pharma Global Development, Inc. Completed No outcome recorded
Phase 1/2 NCT00150319 Jun → Oct 2005 kidney failure Pfizer Terminated No outcome recorded
Phase 1/2 NCT00174473 Jun 2003 → Aug 2005 neutropenia Pfizer Completed No outcome recorded
Phase 215 trials
Phase 2 NCT03672292 Jan 2019 → Mar 2023 invasive aspergillosis Scynexis, Inc. Terminated No outcome recorded
Phase 2 NCT02689713 Jun → Nov 2018 Kenneth Hargreaves Withdrawn No outcome recorded
Phase 2 NCT03327727 Feb 2018 → Jan 2019 invasive aspergillosis Vical Terminated No outcome recorded
Phase 2 NCT04110860 Feb → Jun 2018 pityriasis versicolor Sara Botros Completed No outcome recorded
Phase 2 NCT01887457 Sep 2014 → Nov 2016 aspergillosis, fusariosis, immunodeficiency disease Brynn Chappell Suspended No outcome recorded
Phase 2 NCT01576315 Jun 2014 → Oct 2015 aspergillosis, cystic fibrosis Rennes University Hospital Completed No outcome recorded
Phase 2 NCT01501708 Dec 2011 → Jun 2017 disease related to hematopoietic stem cell transplant, leukemia Shanghai Jiao Tong University School of Medicine Unknown No outcome recorded
Phase 2 NCT01383993 Sep 2011 → May 2013 aspergillosis Pfizer Completed No outcome recorded
Phase 2 NCT02366884 Jul 2011 → Dec 2022 neoplasm Dr. Frank Arguello Cancer Clinic Unknown No outcome recorded
Phase 2 NCT00739934 Dec 2008 → Oct 2009 candidemia Pfizer Completed No outcome recorded
Phase 2/33 trials
Phase 2/3 NCT03230058 Jan 2017 → Mar 2018 fungal infectious disease L.V. Prasad Eye Institute Unknown No outcome recorded
Phase 2/3 NCT01621321 Jun 2013 → Apr 2016 allergic bronchopulmonary aspergillosis Post Graduate Institute of Medical Education and Research, Chandigarh Completed No outcome recorded
Phase 2/3 NCT00159822 Jul 2005 → Dec 2008 aspergillosis Pfizer Completed No outcome recorded
Phase 320 trials
Phase 3 NCT05708625 Jan 2022 → Dec 2023 cutaneous leishmaniasis Zagazig University Unknown No outcome recorded
Phase 3 NCT04824417 Mar 2021 → May 2024 aspergillosis Post Graduate Institute of Medical Education and Research, Chandigarh Completed No outcome recorded
Phase 3 NCT02731638 Sep 2016 → Jul 2018 corneal ulcer, fungal keratitis University of California, San Francisco Completed No outcome recorded
Phase 3 NCT01092832 Oct 2010 → May 2013 candidiasis Pfizer Terminated No outcome recorded
Phase 3 NCT00996736 Apr 2010 → Jul 2012 corneal ulcer, fungal keratitis University of California, San Francisco Completed No outcome recorded
Phase 3 NCT00836875 May 2009 → May 2013 invasive aspergillosis Pfizer Terminated No outcome recorded
Phase 3 NCT00904995 May 2009 → Jul 2010 fungal infectious disease, leukemia M.D. Anderson Cancer Center Completed No outcome recorded
Phase 3 NCT00893555 Apr 2009 → Nov 2016 fungal infectious disease, hematopoietic and lymphoid cell neoplasm Jan-Willem C Alffenaar Completed No outcome recorded
Phase 3 NCT00531479 Jul 2008 → Apr 2011 aspergillosis Pfizer Completed No outcome recorded
Phase 3 NCT00289991 Mar 2006 → Feb 2009 opportunistic mycosis Pfizer Completed No outcome recorded
Phase 420 trials
Phase 4 NCT06582186 Oct 2024 → Oct 2027 expected hematopoietic and lymphoid cell neoplasm, invasive aspergillosis University Hospital, Grenoble Not yet recruiting No outcome recorded
Phase 4 NCT04238884 Jan 2020 fungal infectious disease Instituto de Investigación Hospital Universitario La Paz Unknown No outcome recorded
Phase 4 NCT05380245 Nov 2018 Abdul Wali Khan University Mardan Completed No outcome recorded
Phase 4 NCT03731169 Jan 2018 → Aug 2019 invasive aspergillosis University Health Network, Toronto Completed No outcome recorded
Phase 4 NCT02576366 Jun 2016 → May 2017 Universitaire Ziekenhuizen KU Leuven Completed No outcome recorded
Phase 4 NCT02912156 Jun → Jul 2016 fungal infectious disease Yung Shin Pharm. Ind. Co., Ltd. Completed No outcome recorded
Phase 4 NCT02283905 Jun 2015 → Sep 2020 blastomycosis University of Manitoba Terminated No outcome recorded
Phase 4 NCT02234739 Oct 2014 → Oct 2016 chronic obstructive pulmonary disease, invasive aspergillosis Red Cross Hospital, Hangzhou, China Unknown No outcome recorded
Phase 4 NCT01416025 Jan 2012 → Dec 2014 fungal infectious disease Johns Hopkins University Completed No outcome recorded
Phase 4 NCT01030653 Nov 2009 → Apr 2010 Manjunath Prakash Pai Completed No outcome recorded
Phase not applicable9 trials
NCT06710600 Sep 2022 → Apr 2024 photosensitivity disease Medical University of Vienna Completed No outcome recorded
NCT03827278 Dec 2018 → Dec 2021 penicilliosis Guangxi Medical University Unknown No outcome recorded
NCT02396225 Mar 2015 → Dec 2016 invasive aspergillosis University of Aarhus Terminated No outcome recorded
NCT01344512 Jun 2011 → Sep 2014 University Hospital, Bordeaux Completed No outcome recorded
NCT01104376 Mar 2010 → Apr 2011 efavirenz toxicity Indiana University Completed No outcome recorded
NCT00890708 Nov 2008 → Dec 2011 fungal infectious disease Seoul National University Hospital Completed No outcome recorded
NCT02714504 Aug 2008 → Dec 2014 fusariosis, tinea unguium Federal University of Rio de Janeiro Completed No outcome recorded
NCT00079222 Nov 2003 → Apr 2005 cancer Jonsson Comprehensive Cancer Center Completed No outcome recorded
NCT00023530 Sep 2001 → Aug 2006 graft versus host disease, leukemia, myelodysplastic syndrome, plasma cell myeloma National Heart, Lung, and Blood Institute (NHLBI) Completed No outcome recorded
Phase not stated1 trial
NCT05897294 allergic bronchopulmonary aspergillosis, invasive aspergillosis TFF Pharmaceuticals, Inc. No longer available No outcome recorded
Also used as a comparator or background therapy in 31 trials
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 02 trials
Phase 0 NCT05528354 Background Jun 2022 → Dec 2025 disease related to hematopoietic stem cell transplant Zhejiang University Unknown No outcome recorded
Phase 0 NCT05268718 Comparator Aug 2021 → Dec 2023 corneal ulcer Second Affiliated Hospital, School of Medicine, Zhejiang University Unknown No outcome recorded
Phase 15 trials
Phase 1 NCT06616168 Background Sep 2023 → Aug 2026 overdue bacterial vaginosis Danylo Halytsky Lviv National Medical University Active not recruiting No outcome recorded
Phase 1 NCT00833482 Comparator Sep 2009 → Jul 2010 HIV infectious disease Bristol-Myers Squibb Completed No outcome recorded
Phase 1 NCT01080651 Comparator Dec 2008 → Mar 2009 invasive aspergillosis Seoul National University Hospital Completed No outcome recorded
Phase 1 NCT00942773 Comparator Dec 2008 → Mar 2009 Seoul National University Hospital Completed No outcome recorded
Phase 1 NCT00353158 Comparator May 2007 → Sep 2011 bacterial infectious disease, fungal infectious disease National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) Completed No outcome recorded
Phase 1/22 trials
Phase 1/2 NCT04988555 Background Feb 2022 → Jun 2027 expected acute lymphoblastic leukemia, acute myeloid leukemia, myelodysplastic syndrome, plasma cell myeloma Sumitomo Pharma America, Inc. Recruiting No outcome recorded
Phase 1/2 NCT00557362 Comparator Nov 2007 → Aug 2008 fungal keratitis University of California, San Francisco Completed No outcome recorded
Phase 24 trials
Phase 2 NCT07215273 Comparator Feb → Dec 2026 expected fungal infectious disease Elion Therapeutics, Inc. Recruiting No outcome recorded
Phase 2 NCT06680544 Comparator Nov 2024 → Mar 2025 overdue dermatophytosis Sheikh Zayed Medical College Not yet recruiting No outcome recorded
Phase 2 NCT04294641 Background May 2021 → Jun 2024 chronic graft versus host disease National Cancer Institute (NCI) Completed No outcome recorded
Phase 2 NCT01207128 Comparator Feb 2011 → Jan 2012 invasive aspergillosis University of Arkansas Withdrawn No outcome recorded
Phase 2/31 trial
Phase 2/3 NCT03799809 Comparator Dec 2016 → Dec 2018 pulmonary aspergilloma All India Institute of Medical Sciences Unknown No outcome recorded
Phase 311 trials
Phase 3 NCT06774144 Comparator Oct 2025 → Dec 2028 expected fungal infectious disease Fernanda P Silveira, MD, MS Enrolling by invitation No outcome recorded
Phase 3 NCT04876716 Background May 2021 → May 2024 invasive aspergillosis Erasmus Medical Center Terminated No outcome recorded
Phase 3 NCT03471988 Comparator Apr 2018 → Apr 2021 systemic mycosis Asahi Kasei Therapeutics Corporation Completed No outcome recorded
Phase 3 NCT02180165 Comparator Jul 2014 → Jan 2018 aspergillosis Merck Sharp & Dohme LLC Completed No outcome recorded
Phase 3 NCT01503515 Comparator Mar 2013 → Dec 2019 fungal infectious disease, hematopoietic and lymphoid cell neoplasm Children's Oncology Group Completed No outcome recorded
Phase 43 trials
Phase 4 NCT07072923 Comparator Sep 2025 → Jul 2027 expected osteomyelitis University of Arizona Not yet recruiting No outcome recorded
Phase 4 NCT00548262 Background Feb 2008 → Oct 2009 candidemia Pfizer Completed No outcome recorded
Phase 4 NCT00496197 Background Jul 2007 → Jun 2010 candidiasis Pfizer Completed No outcome recorded
Phase not applicable3 trials
NCT07244367 Comparator Sep 2025 → Sep 2026 expected acute myeloid leukemia Sohag University Recruiting No outcome recorded
NCT03138785 Background Jan 2015 → Jun 2017 Farabi Eye Hospital Unknown No outcome recorded
NCT02328053 Background Feb 2014 → Jul 2015 mycotic corneal ulcer Aravind Eye Care System Unknown No outcome recorded

Evidence & citations 18 cited values

Every value below carries the sentence it was read from. 132 sources stand behind the page.

FieldValueCited text
Known as voriconazole “Calcium sulfate beads will be loaded with best available antibiotics based on surgeon/infectious disease specialist determination from the following options (vancomycin,...” NCT07072923
126

Voriconazole or isavuconazole or posaconazole will be dosed according to the SPC and according to the route of administration (IV or orally) that is preferred by the treating physician.” NCT04876716

“This is a study to investigate the pharmacokinetics, safety and tolerability of intravenous voriconazole and SBECD in patients with moderate renal insufficiency” NCT00150319

“To assess the pharmacokinetics (PK) of voriconazole and anidulafungin in patients with invasive aspergillosis (IA) in comparison with other populations” PMID 24913161 Jun 2014

“This is a study to investigate the safety and efficacy of voriconazole for the treatment of candidemia in critically ill non-neutropenic patients” NCT00163111

“Triazoles (Fluconazole, Itraconazole, Voriconazole), Imidazoles (Ketoconazole), Nystatin and Amphotericin B are used the most” NCT06616168

“topical antifungal medications like natamycin eye drops and voriconazole eye drops” NCT02328053

“Itraconazole, Amphotericin B liposomal, Fluconazole, Terbinafine, VoriconazoleNCT02366884

“if Voriconazole or Posaconazole is used to prevent or treat fungal infections” NCT05528354

Voriconazole dose will be adjusted based on per protocol obtained TDM levels” NCT01416025

Voriconazole is used for recipients with risk factors for mould infections” NCT06774144

“Oral dose of omeprazole, voriconazole, itraconazole, or rifampicin” NCT05822544

Voriconazole 200 mg 1x2 administrated on days” NCT07244367

“Posaconazole, Voriconazole, or Fluconazole” NCT04988555

voriconazole (Voriconazol Aristo®) 200mg” NCT06710600

NCT02180165

NCT00066599

NCT00423163

NCT00647907

NCT00940017

NCT00003031

NCT00288197

NCT04229303

NCT03827278

NCT01503515

NCT03515382

NCT00159822

NCT01787032

NCT02014558

NCT00023530

NCT02689713

NCT00005912

NCT03760276

NCT00620074

NCT05708625

NCT00996736

NCT04072640

NCT01501708

NCT02906176

NCT06680544

NCT00150345

NCT06493409

NCT00418951

NCT00015665

NCT01621321

NCT00152594

NCT03672292

NCT01080651

NCT02631954

NCT04872231

NCT00855101

NCT07457203

NCT00548262

NCT00143312

NCT01207128

NCT00174473

NCT01539330

NCT05458102

NCT01030653

NCT01092832

NCT04551963

NCT02396225

NCT04576325

NCT00942773

NCT00739934

NCT04824417

NCT05330000

NCT00496197

NCT05264142

NCT07426042

NCT00413218

NCT01950507

NCT02912156

NCT02576366

NCT07215273

NCT05897294

NCT00412893

NCT02381080

NCT00289991

NCT03471988

NCT02283905

NCT01344512

NCT01576315

NCT00893555

NCT00136968

NCT02227797

NCT02731638

NCT03799809

NCT00238355

NCT01657201

NCT05268718

NCT00624143

NCT02234739

NCT05380245

NCT01383993

NCT03327727

NCT00001646

NCT00689338

NCT04294641

NCT00075803

NCT00455364

NCT00792246

NCT00557362

NCT00833482

NCT04110860

NCT00001940

NCT04145583

NCT00353158

NCT00904995

NCT03731169

NCT00079222

NCT00059878

NCT02714504

NCT00997035

NCT06582186

NCT00556998

NCT00001757

NCT00300677

NCT00890708

NCT03230058

NCT04865419

NCT01188759

NCT03138785

NCT00836875

NCT01104376

NCT00001810

NCT04238884

Known as NSC-759888 ChEMBL registry synonym — accepted as the source's own label CHEMBL638
Known as UK-109,496 ChEMBL registry synonym — accepted as the source's own label CHEMBL638
Known as Vaway FC Tablets Vaway FC Tablets 200mg (Voriconazole)” NCT02912156
Known as VFEND “The purpose of this study was to evaluate the pharmacokinetic equivalency of a test formulation and reference formulation (Vfend®) of Voriconazole.” PMID 36869387 Mar 2023
7

“Study to Evaluate the Pharmacokinetic Properties of SYP-1018 (Voriconazole-loaded PNP) and Voriconazole (Vfend)” NCT01657201

“To be determined mg of Voriconazole (Vfend®, anti-fungal agent)” NCT03760276

Vfend (voriconazole) intravenous infusion” NCT02906176

“Antifungal drug. VORICONAZOL. (VFEND®)” NCT00386802

“Drug: voriconazole (Vfend)” NCT00150345

“Drug: Vfend (voriconazole)” NCT00496197

NCT01887457

Known as VFEND FC Tablets VFEND FC Tablets 200mg (Voriconazole)” NCT02912156
Known as VFEND I.V. “Voriconazole (VFEND® I.V., Pfizer, New York, NY) will be prepared as a 1% solution.” NCT00557362
Known as VFend(R) “To evaluate the efficacy of voriconazole (VFend(R)) as first line treatment for proven chronic bronchopulmonary aspergillosis, in minimally immunocompromised or...” NCT00159822
Known as Vori Voriconazole (Vori) 6mg/kg BID IV loading dose on Day 1 followed by 4mg/kg IV BID thereafter.” NCT07215273
Known as VORICONAZOL ClinicalTrials.gov intervention name — accepted as the source's own label NCT00386802
Known as Voriconazol Aristo “voriconazole (Voriconazol Aristo®) 200mg” NCT06710600
Known as Voriconazole accord ChEMBL registry synonym — accepted as the source's own label CHEMBL638
Known as Voriconazole hikma (previously voriconazole hospira) ChEMBL registry synonym — accepted as the source's own label CHEMBL638
Action Inhibit “Voriconazole inhibits an essential step of the biosynthesis of an important component of the fungal cell wall (ergosterol).” NCT00418951
Modality Small molecule “Voriconazole is a new triazole that has shown in phase II studies to be very active against Aspergillus sp.” NCT00015665
Route Intravenous “available in an intravenous and oral formulation” NCT00001646
Route Oral “available in an intravenous and oral formulation” NCT00001646
Target CYP2B6 “Efavirenz, a nonnucleoside HIV-1 reverse transcriptase inhibitor, is mainly cleared by CYP2B6, an enzyme strongly inhibited in vitro by voriconazole.” PMID 27600044 Oct 2016