Therapeutic Exploratory Study of Comparing Natamycin and Voriconazole to Treat Fungal Corneal Ulcer

Phase 1/2 Completed 120 enrolled University of California, San Francisco Aravind Eye Hospitals, India · collab Dartmouth-Hitchcock Medical Center · collab That Man May See, Inc. · collab

RandomizedParallel-groupQuadruple-blindTreatment

Summary

We evaluated whether voriconazole is a superior treatment to natamycin for filamentous fungal keratitis in a randomized, masked, controlled trial. This is a therapeutic exploratory study to investigate the safety and feasibility of conducting a larger study and to generate preliminary data.

Timeline

Start: 2007-11
Primary completion: 2008-08
Completion: 2008-08

Publications

Prajna NV, Mascarenhas J, Krishnan T, Reddy PR, Prajna L, Srinivasan M, Vaitilingam CM, Hong KC, Lee SM, McLeod SD, Zegans ME, Porco TC, Lietman TM, Acharya NR. Comparison of natamycin and voriconazole for the treatment of fungal keratitis. Arch Ophthalmol. 2010 Jun;128(6):672-8. doi: 10.1001/archophthalmol.2010.102.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Natamycin	Small molecule	5 %	Topical
Comparator	Voriconazole	Small molecule	1 %	Topical

Therapeutic Exploratory Study of Comparing Natamycin and Voriconazole to Treat Fungal Corneal Ulcer

Summary

Timeline

Publications

Drugs

Indications