drugset / Trial / NCT00418951
Liposomal Amphotericin B (Ambisome) Versus Oral Voriconazole for the Prevention of Invasive Fungal Infections
RandomizedParallel-groupOpen-labelPrevention
Summary
The goal of this clinical research study is to compare the effectiveness of liposomal amphotericin B given three times per week , versus liposomal amphotericin B given once per week, versus oral voriconazole in the prevention of fungal infections in patients with acute myeloid leukemia (AML) or myelodysplastic syndromes MDS who are receiving chemotherapy. The safety of these treatments will also be studied and compared.
Timeline
- Start
- 2006-11
- Primary completion
- 2009-10
- Completion
- 2009-10
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Amphotericin B | Unknown | 3 mg/kg | Intravenous |
| Subject | Amphotericin B | Unknown | 9 mg/kg | Intravenous |
| Subject | Voriconazole | Small molecule | 200 mg | Oral |