drugset / Trial / NCT00418951

Liposomal Amphotericin B (Ambisome) Versus Oral Voriconazole for the Prevention of Invasive Fungal Infections

NCT00418951

Phase 2 Completed 120 enrolled M.D. Anderson Cancer Center
RandomizedParallel-groupOpen-labelPrevention

Summary

The goal of this clinical research study is to compare the effectiveness of liposomal amphotericin B given three times per week , versus liposomal amphotericin B given once per week, versus oral voriconazole in the prevention of fungal infections in patients with acute myeloid leukemia (AML) or myelodysplastic syndromes MDS who are receiving chemotherapy. The safety of these treatments will also be studied and compared.

Timeline

Start
2006-11
Primary completion
2009-10
Completion
2009-10

Drugs

EvaluationDrugModalityDoseRoute
Subject Amphotericin B Unknown 3 mg/kg Intravenous
Subject Amphotericin B Unknown 9 mg/kg Intravenous
Subject Voriconazole Small molecule 200 mg Oral