drugset / Trial / NCT01501708
Caspofungin Based Combined Anti-fungal Therapy for Proven or Probable Invasive Fungal Infection
NaSingle-groupOpen-labelTreatment
Summary
In this prospective phase II observational study, we plan to assess the efficacy and tolerability of caspofungin based combined anti-fungal therapy for proven or probable IFI in a group of patients received allo-HSCT transplantation with high risk of IFI: HLA matched unrelated donor or mismatched donor conditioning with ATG containing regimen or present III-IV aGVHD or extensive GVHD undergoing high-dose steroid treatment.
Timeline
- Start
- 2011-12
- Primary completion
- 2017-06
- Completion
- 2017-12
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Amphotericin B | Unknown | 3 mg/kg | — |
| Subject | Caspofungin | Other / unclassified | 50 mg | — |
| Subject | Voriconazole | Small molecule | 4 mg/kg | — |
| Background | Fluconazole | Small molecule | — | — |
| Background | Itraconazole | Small molecule | — | — |