A Study Evaluating Drug-Drug Interaction (DDI) Between HSK3486 Injectable Emulsion and Voriconazole Tablets

Phase 1 Completed 16 enrolled Sichuan Haisco Pharmaceutical Group Co., Ltd

RandomizedCrossoverOpen-labelTreatment

Summary

This is a single-center, open-label, randomized, two-stage, two-way crossover study evaluating the effect of voriconazole on the PK, PD, and safety of HSK3486 in healthy subjects.

Timeline

Start: 2019-12-14
Primary completion: 2020-01-06
Completion: 2020-05-09

Publications

Bian Y, Hu T, Deng Q, Ma S, Jiao Y, Shi J, Jiang N, Hu M, Wang Y, Liu X, Zhang Z, Huang C, Zhang H, Miao L. Effects of Voriconazole on the Safety, Pharmacokinetics and Pharmacodynamics of Ciprofol (HSK3486), a Novel Intravenous Anaesthetic, in Healthy Participants: A Prospective, Randomized, Crossover Clinical Trial. Drug Des Devel Ther. 2026 Jan 8;20:562125. doi: 10.2147/DDDT.S562125. eCollection 2026.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Cipepofol	Small molecule	0.4 mg/kg	Intravenous
Subject	Voriconazole	Small molecule	200 mg	Oral

Indications

No indication recorded.