Metformin in Non-Alcoholic Fatty Liver Disease

Summary

The study evaluates the use of the antidiabetic medicine metformin in nonalcoholic fatty liver disease.

Timeline

Start

2004-11

Primary completion

—

Completion

2008-06

Outcome

Missed primary endpoint

paper No significant differences between treatment with metformin or placebo were observed for changes in liver steatosis, assessed either histologically or by CT PMID 19811343 ↗

Publications

• Haukeland JW, Dahl TB, Yndestad A, Gladhaug IP, Loberg EM, Haaland T, Konopski Z, Wium C, Aasheim ET, Johansen OE, Aukrust P, Halvorsen B, Birkeland KI. Fetuin A in nonalcoholic fatty liver disease: in vivo and in vitro studies. Eur J Endocrinol. 2012 Mar;166(3):503-10. doi: 10.1530/EJE-11-0864. Epub 2011 Dec 14.
• Haukeland JW, Konopski Z, Eggesbo HB, von Volkmann HL, Raschpichler G, Bjoro K, Haaland T, Loberg EM, Birkeland K. Metformin in patients with non-alcoholic fatty liver disease: a randomized, controlled trial. Scand J Gastroenterol. 2009;44(7):853-60. doi: 10.1080/00365520902845268.

Drugs

Indications