drugset / Trial / NCT00309179
A Phase II Study of the Safety and Efficacy of E7820 Plus Cetuximab in Colorectal Cancer, Preceded by a Run-in Study in Advanced Solid Tumors
NaSingle-groupOpen-labelTreatment
Summary
This study proposes to determine the safety of the administration of E7820 plus cetuximab and explore the MTD of the combination in a Phase Ib study. In addition, the efficacy of this combination will be explored in patients with colorectal cancer in the Phase II proof of concept phase of the study.
Timeline
- Start
- 2007-09-24
- Primary completion
- 2009-12-14
- Completion
- 2017-02-13
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Cetuximab | Monoclonal antibody | — | — |
| Subject | E7820 | Small molecule | — | — |
| Subject | Irinotecan | Small molecule | 40 mg/m2 | — |