Study to Compare the Efficacy and Safety of Pitavastatin and Simvastatin

Summary

The purpose of this study is to compare the efficacy and safety of pitavastatin with that of simvastatin.

Timeline

Start

2005-09

Primary completion

2006-10

Completion

2006-10

Outcome

Met primary endpoint

paper Pitavastatin 2 mg showed significantly better reductions of LDL-C (p = 0.014) PMID 19785568 ↗

paper Pitavastatin was considered superior to simvastatin in terms of percent reduction of LDL-C in the lower dose group comparison PMID 19785568 ↗

paper proved to be equivalent to simvastatin in percent reduction of LDL-C in the higher-dose group. PMID 19785568 ↗

Publications

• Ose L, Budinski D, Hounslow N, Arneson V. Comparison of pitavastatin with simvastatin in primary hypercholesterolaemia or combined dyslipidaemia. Curr Med Res Opin. 2009 Nov;25(11):2755-64. doi: 10.1185/03007990903290886.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Pitavastatin	Small molecule	2 mg	—
Subject	Pitavastatin	Small molecule	4 mg	—
Comparator	Simvastatin	Small molecule	20 mg	—
Comparator	Simvastatin	Small molecule	40 mg	—

Indications