Aminophylline in Bradyasystolic Cardiac Arrest

Phase 2 Completed 966 enrolled Vancouver General Hospital Heart and Stroke Foundation of Canada · collab Vancouver Coastal Health Research Institute · collab

RandomizedParallel-groupDouble-blindTreatment

Summary

The purpose of this study is to evaluate the effect of aminophylline in patients with out-of-hospital bradyasystolic cardiac arrest.

Timeline

Start: 2001-01
Primary completion: —
Completion: 2004-07

Outcome

Missed primary endpoint

paper difference 0.8%; 95% CI -4.6% to 6.2%; p=0.778 PMID 16698410 ↗

paper we noted no evidence that it significantly increases the proportion of patients who achieve ROSC after bradyasystolic cardiac arrest. PMID 16698410 ↗

Publications

Results Abu-Laban RB, McIntyre CM, Christenson JM, van Beek CA, Innes GD, O'Brien RK, Wanger KP, McKnight RD, Gin KG, Zed PJ, Watts J, Puskaric J, MacPhail IA, Berringer RG, Milner RA. Aminophylline in bradyasystolic cardiac arrest: a randomised placebo-controlled trial. Lancet. 2006 May 13;367(9522):1577-84. doi: 10.1016/S0140-6736(06)68694-7.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Aminophylline	Small molecule	250 mg	Intravenous