Drugs / Aminophylline
Regulatory milestones approvals, filings & regulatory actions · 1 recorded
| Milestone | Jurisdiction | Brand | Indication | Date | Sentence it was read from |
|---|---|---|---|---|---|
| Approved | US (FDA) | AMINOPHYLLIN | — | 1940-04-19 | fda.gov ↗ |
Trials 20
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| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 01 trial | ||||||
| Phase 0 | NCT01240824 | Jul 2010 → Feb 2011 | urinary bladder cancer | University of Virginia | Completed | No outcome recorded |
| Phase 11 trial | ||||||
| Phase 1 | NCT01794078 | Sep 2013 → Sep 2014 | acute mountain sickness | Robert J Noveck, M.D. | Completed | No outcome recorded |
| Phase 24 trials · 1 missed | ||||||
| Phase 2 | NCT07617896 | May 2026 → Apr 2027 expected | ureterolithiasis, urolithiasis | Beni-Suef University | Recruiting | No outcome recorded |
| Phase 2 | NCT07623876 | May 2026 → Apr 2027 expected | urolithiasis | Beni-Suef University | Recruiting | No outcome recorded |
| Phase 2 | NCT07617948 | Apr 2026 → Mar 2027 expected | acute kidney injury, anuria, ureterolithiasis, urinary tract obstruction | Beni-Suef University | Recruiting | No outcome recorded |
| Phase 2 | NCT00312273 | Jan 2001 → Jul 2004 | cardiac arrest | Vancouver General Hospital | Completed | Missed primary |
| Phase 2/31 trial | ||||||
| Phase 2/3 | NCT06196853 | Dec 2025 → Sep 2026 overdue | acute kidney injury, renal tubule disorder | Mahidol University | Not yet recruiting | No outcome recorded |
| Phase 31 trial · 1 met primary | ||||||
| Phase 3 | NCT02522013 | Oct 2015 → Oct 2016 | intracranial hypotension | The First Affiliated Hospital of Zhengzhou University | Completed | Met primary |
| Phase 46 trials · 2 met primary | ||||||
| Phase 4 | NCT05666219 | Dec 2022 → Dec 2023 | heart conduction disease, inferior myocardial infarction | National Institute of Cardiovascular Diseases, Pakistan | Withdrawn | No outcome recorded |
| Phase 4 | NCT04101500 | Apr 2019 → Dec 2020 | chronic obstructive pulmonary disease | Union Hospital, Tongji Medical College, Huazhong University of Science and Technology | Unknown | No outcome recorded |
| Phase 4 | NCT01655524 | Jul 2012 → Jul 2014 | coronary artery disorder | Rush University Medical Center | Withdrawn | No outcome recorded Stop: Enrollment |
| Phase 4 | NCT01336140 | Jun 2011 → May 2012 | — | Rush University Medical Center | Completed | Met primary |
| Phase 4 | NCT01250496 | Nov 2010 → Nov 2011 | — | Rush University Medical Center | Terminated | Met primary Stop: Enrollment |
| Phase 4 | NCT01594489 | Jan 2009 → Sep 2012 | acute kidney injury | Ospedale Misericordia e Dolce | Completed | No outcome recorded |
| Phase not applicable6 trials · 1 missed | ||||||
| — | NCT06830577 | Mar 2025 → Jan 2026 overdue | ureteral disorder, urolithiasis | Ain Shams University | Recruiting | No outcome recorded |
| — | NCT06125665 | Nov 2023 → Apr 2024 | chronic obstructive pulmonary disease, morbid obesity | Tanta University | Unknown | No outcome recorded |
| — | NCT05738135 | Feb → Aug 2023 | — | Tanta University | Completed | No outcome recorded |
| — | NCT05705050 | Feb → Jun 2023 | — | Tanta University | Completed | No outcome recorded |
| — | NCT01759862 | Nov 2012 → Jan 2017 | — | Stanford University | Completed | Missed primary |
| — | NCT01280071 | — | — | Tel-Aviv Sourasky Medical Center | Unknown | No outcome recorded |
| Comparator or background therapy20 trials | ||||||
| Phase 0 | NCT02983422 Comparator | Dec 2016 → Jun 2017 | acute kidney injury | Shanghai Jiao Tong University Affiliated Sixth People's Hospital | Unknown | No outcome recorded |
| Phase 1 | NCT04151381 Comparator | Nov → Dec 2019 | — | Beni-Suef University | Unknown | No outcome recorded |
| Phase 1 | NCT03152942 Comparator | Oct 2017 → Oct 2018 | obstetric disorder | St Stephens Aids Trust | Unknown | No outcome recorded |
| Phase 1 | NCT01530464 Comparator | Feb → Apr 2012 | pulmonary hypertension | Thies Schroeder | Completed | No outcome recorded |
| Phase 1 | NCT01587027 Comparator | Dec 2011 → Feb 2012 | altitude sickness | Poudre Valley Health System | Completed | No outcome recorded |
| Phase 1/2 | NCT01702025 Comparator | Jun → Dec 2012 | — | Colorado State University | Completed | No outcome recorded |
| Phase 2 | NCT07528118 Background | Aug 2023 → Jun 2024 | — | Sargodha Medical College | Completed | No outcome recorded |
| Phase 2 | NCT01022151 Comparator | Nov 2007 → Jul 2010 | — | King Faisal University | Completed | No outcome recorded |
| Phase 2/3 | NCT05933642 Comparator | Jul → Dec 2023 | acute kidney injury | University of Malaya | Unknown | No outcome recorded |
| Phase 3 | NCT07011134 Comparator | Jun → Aug 2025 | — | Hany Mohammed El-Hadi Shoukat Mohammed | Completed | No outcome recorded |
| Phase 3 | NCT03897335 Comparator | Feb 2019 → Feb 2023 | acute kidney injury | Le Bonheur Children's Hospital | Unknown | No outcome recorded |
| Phase 3 | NCT00442338 Comparator | Mar → Aug 2007 | asthma | Organon and Co | Completed | Missed primary |
| Phase 4 | NCT05655806 Comparator | Dec 2022 → Jun 2023 | — | Cairo University | Unknown | No outcome recorded |
| Phase 4 | NCT05552404 Comparator | Oct → Dec 2022 | — | Ain Shams University | Completed | No outcome recorded |
| Phase 4 | NCT03997006 Comparator | Jan 2019 → Jan 2020 | intracranial hypotension | Damanhour Teaching Hospital | Completed | No outcome recorded |
| — | NCT07348510 Comparator | Jan → Jul 2026 overdue | — | Cairo University | Recruiting | No outcome recorded |
| — | NCT04274413 Background | Feb 2021 | CFTR-related disorder, cystic fibrosis | The Hospital for Sick Children | Withdrawn | No outcome recorded Stop: Business |
| — | NCT03296579 Comparator | Jun → Nov 2018 | acute asthma, childhood onset asthma | University of British Columbia | Unknown | No outcome recorded |
| — | NCT02310789 Background | Jul 2015 → Aug 2016 | cystic fibrosis | Richard Barry Moss | Completed | No outcome recorded |
| — | NCT01245595 Comparator | Nov 2010 → May 2014 | acute kidney injury | Stanford University | Completed | No outcome recorded |
Evidence & citations 5 cited values
Every value below carries the sentence it was read from. 41 sources stand behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | Aminophylline | “Lastly, beta-adrenergic sweating will be stimulated by injecting a combination of the following drugs: atropine, isoproterenol, and aminophylline (β-cocktail).” NCT04274413 ↗39“Cocktail composed of atropine (280µM), isoproterenol (160µM), and aminophylline (20 mM).” NCT02310789 ↗ “Aminophylline” NCT01655524 ↗ |
| Known as | aminophylline hydrate | “Drug: aminophylline hydrate” NCT00442338 ↗ |
| Action | Inhibit | “Aminophylline is a competitive antagonist of adenosine.” NCT00312273 ↗ |
| Modality | Small molecule | “Aminophylline, a methylxanthine derivative” NCT06830577 ↗ |
| Route | Intravenous | “receive intravenous aminophylline (250 mg, and an additional 250 mg if necessary)” PMID 16698410 ↗ May 2006 |