A Study of a Glaucoma Therapy to Treat Open-Angle Glaucoma or Ocular Hypertension

Phase 3 Completed 523 enrolled Alcon Research

RandomizedParallel-groupDouble-blindTreatment

Summary

The purpose of this study is to determine whether a glaucoma therapy is safe and effective in treating patients with open-angle glaucoma or ocular hypertension.

Timeline

Start: 2005-11
Primary completion: 2007-01
Completion: 2007-01

Outcome

Met primary endpoint

paper which were statistically and clinically superior to that of either brinzolamide 1% (5.1-5.6 mmHg) or timolol 0.5% (5.7-6.9 mmHg). PMID 18538406 ↗

Publications

Results Kaback M, Scoper SV, Arzeno G, James JE, Hua SY, Salem C, Dickerson JE, Landry TA, Bergamini MV; Brinzolamide 1%/Timolol 0.5% Study Group. Intraocular pressure-lowering efficacy of brinzolamide 1%/timolol 0.5% fixed combination compared with brinzolamide 1% and timolol 0.5%. Ophthalmology. 2008 Oct;115(10):1728-34, 1734.e1-2. doi: 10.1016/j.ophtha.2008.04.011. Epub 2008 Jun 5.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Brinzolamide	Small molecule	10 mg/ml	Other
Subject	Timolol	Other / unclassified	5 mg/ml	Other