Efficacy of Metformin in PCOS: Metabolic and Hormonal Factors

Summary

Hypothesis: Metformin treatment normalises hormone values and metabolic parameters in women with PCOS. Ovulation is restored and bleeding periods become regular. Fifty women with PCOS (Rotterdam criteria) are randomised to either placebo or metformin for 6 months. After a wash-out period of 3 months, the opposite treatment is given for another 6 months. Measurements are performed before ech treatment period, every second month during treatment and after completing treatment.

Timeline

Start

2001-08

Primary completion

—

Completion

2004-09

Drugs

Indications