Nitrous Oxide for Analgesia During Colonoscopy

Summary

The purpose of the study is to determine the analgetic effect of nitrous oxide during colonoscopy, compared to no sedation and intravenous (IV) sedation.

Timeline

Start

2006-04

Primary completion

2008-09

Completion

2008-09

Outcome

Missed primary endpoint

paper Median patient-reported pain was 2 in both the nitrous oxide group and the control group (interquartile range 2-3 in both groups). PMID 22136779 ↗

paper CONCLUSION: Nitrous oxide given intermittently is not an effective substitution for intravenous on-demand sedation and analgesics in the setting of colonoscopy without sedation. PMID 22136779 ↗

Publications

• Loberg M, Furholm S, Hoff I, Aabakken L, Hoff G, Bretthauer M. Nitrous oxide for analgesia in colonoscopy without sedation. Gastrointest Endosc. 2011 Dec;74(6):1347-53. doi: 10.1016/j.gie.2011.07.071.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Nitrous Oxide	Other / unclassified	—	Inhaled

Indications

No indication recorded.