Acetaminophen Before Vaccines for Infants Study (AVIS)

Phase 3 Completed 374 enrolled Kaiser Permanente Centers for Disease Control and Prevention · collab

RandomizedParallel-groupTriple-blindPrevention

Summary

The purpose of this study is to see whether giving acetaminophen (the medicine in Tylenol) for routine infant vaccinations is helpful in preventing fever or other symptoms.

Timeline

Start: 2006-05
Primary completion: 2009-09
Completion: 2009-09

Publications

Results Jackson LA, Peterson D, Dunn J, Hambidge SJ, Dunstan M, Starkovich P, Yu O, Benoit J, Dominguez-Islas CP, Carste B, Benson P, Nelson JC. A randomized placebo-controlled trial of acetaminophen for prevention of post-vaccination fever in infants. PLoS One. 2011;6(6):e20102. doi: 10.1371/journal.pone.0020102. Epub 2011 Jun 17.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Acetaminophen	Small molecule	10 mg/kg	—
Comparator	Acetaminophen	Small molecule	15 mg/kg	—

Indications

No indication recorded.