Renal Transplantation and Inhaled Anesthetic Sevoflurane (SEVOREIN)

Summary

Renal transplantation is characterized by ischemia-reperfusion lesions in allograft. In a previous study, Julier and al. (Anesthesiology 2003) have demonstrated that sevoflurane reduces glomerular lesions in kidney of patients undergoing a cardiovascular surgery and présenting with ischemia-reperfusion phenomena. The purpose of the study is to evaluate the effects of sevoflurane on the recovery of renal graft function in patients after kidney transplantation. This study will be a randomized, double blinded, controlled clinical trial and 120 patients undergoing renal allograft transplantation will be included. Patients will be divided into 2 groups: one group of patients who will receive sevoflurane (evaluated treatment) for anaesthesia and the other one who will receive propofol (reference treatment). We will evaluate renal function for one year after transplantation. Ours results will confirm or not that sevoflurane protects kidney function from ischemia-reperfusion lesions.

Timeline

Start

2006-06

Primary completion

2010-02

Completion

2010-06

Publications

• Results Nouette-Gaulain K, Lemoine P, Cros AM, Sztark F. [Induction of anaesthesia with target-controlled inhalation of sevoflurane in adults with the ZEUS anaesthesia machine]. Ann Fr Anesth Reanim. 2005 Jul;24(7):802-6. doi: 10.1016/j.annfar.2005.04.029. French.

Drugs

Indications