Morphine-Sparing Efficacy Of Parecoxib In Pain Treatment After Radical Prostatectomy

Phase 4 Terminated 105 enrolled Pfizer

RandomizedParallel-groupDouble-blindTreatment

Summary

The primary objective of this study is to demonstrate the opioid-sparing efficacy of parecoxib 40 mg intravenously given as a loading dose followed by 20 mg intravenously in the 24 hours after the end of surgery.

Timeline

Start: 2006-12
Primary completion: 2010-09
Completion: 2010-09

Publications

Dirkmann D, Groeben H, Farhan H, Stahl DL, Eikermann M. Effects of parecoxib on analgesia benefit and blood loss following open prostatectomy: a multicentre randomized trial. BMC Anesthesiol. 2015 Mar 9;15:31. doi: 10.1186/s12871-015-0015-y. eCollection 2015.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Parecoxib	Small molecule	20 mg	Intravenous
Comparator	Morphine	Other / unclassified	1 mg	—

Indications

No indication recorded.